Optimal vaccination choice, vaccination games, and rational exemption: An appraisal (original) (raw)

A Game-Theoretic Analysis of Childhoof Vaccination Behavior: Nash Versus Kant

SSRN Electronic Journal, 2022

Whether or not to vaccinate one's child is a decision that a parent may approach in several ways. The vaccination game, in which parents must choose whether to vaccinate a child against a disease, is one with positive externalities (herd immunity). In some societies, not vaccinating is an increasingly prevalent behavior, due to deleterious side effects that parents believe may accompany vaccination. The standard game-theoretic approach assumes that parents make decisions according to the Nash behavioral protocol, which is individualistic and non-cooperative. Because of the positive externality that each child's vaccination generates for others, the Nash equilibrium suffers from a free-rider problem. However, in more solidaristic societies, parents may behave cooperatively-they may optimize according to the Kantian protocol, in which the equilibrium is efficient. We test, on a sample of six countries, whether childhood vaccination behavior conforms better to the individualistic or cooperative protocol. In order to do so, we conduct surveys of parents in these countries, to ascertain the distribution of beliefs concerning the subjective probability and severity of deleterious side effects of vaccination. We show that in all the countries of our sample the Kant model dominates the Nash model. We conjecture that, due to the free-rider problem inherent in the Nash equilibrium, a social norm has evolved, quite generally, inducing parents to vaccinate with higher probability than they would in the noncooperative solution. Kantian equilibrium offers one precise version of such a social norm.

A Game-Theoretic Analysis of Childhood Vaccination Behavior: Nash Versus Kant

SSRN Electronic Journal, 2021

Whether or not to vaccinate one's child is a decision that a parent may approach in several ways. The vaccination game, in which parents must choose whether to vaccinate a child against a disease, is one with positive externalities (herd immunity). In some societies, not vaccinating is an increasingly prevalent behavior, due to deleterious side effects that parents believe may accompany vaccination. The standard game-theoretic approach assumes that parents make decisions according to the Nash behavioral protocol, which is individualistic and non-cooperative. Because of the positive externality that each child's vaccination generates for others, the Nash equilibrium suffers from a free-rider problem. However, in more solidaristic societies, parents may behave cooperatively-they may optimize according to the Kantian protocol, in which the equilibrium is efficient. We test, on a sample of six countries, whether childhood vaccination behavior conforms better to the individualistic or cooperative protocol. In order to do so, we conduct surveys of parents in these countries, to ascertain the distribution of beliefs concerning the subjective probability and severity of deleterious side effects of vaccination. We show that in all the countries of our sample the Kant model dominates the Nash model. We conjecture that, due to the free-rider problem inherent in the Nash equilibrium, a social norm has evolved, quite generally, inducing parents to vaccinate with higher probability than they would in the noncooperative solution. Kantian equilibrium offers one precise version of such a social norm.

Behavioral incentives in a vaccination-dilemma setting with optional treatment

Physical Review E

Social dilemmas are situations wherein individuals choose between selfish interest and common good. One example of this is the vaccination dilemma, in which an individual who vaccinates at a cost protects not only himself but also others by helping maintain a common good called herd immunity. There is, however, a strong incentive to forgo vaccination, thus avoiding the associated cost, all the while enjoying the protection of herd immunity. To analyze behavioral incentives in a vaccination-dilemma setting in which an optional treatment is available to infected individuals, we combined epidemiological and game-theoretic methodologies by coupling a disease-spreading model with treatment and an evolutionary decision-making model. Extensive numerical simulations show that vaccine characteristics are more important in controlling the treatment adoption than the cost of treatment itself. The main effect of the latter is that expensive treatment incentivizes vaccination, which somewhat surprisingly comes at a little cost to society. More surprising is that the margin for a true synergy between vaccine and treatment in reducing the final epidemic size is very small. We furthermore find that society-centered decision making helps protect herd immunity relative to individual-centered decision making, but the latter may be better in establishing a novel vaccine. These results point to useful policy recommendations as well as to intriguing future research directions.

Herd immunity and a vaccination game: An experimental study

PLOS ONE, 2020

Would the affected communities voluntarily obtain herd immunity if a cure for COVID-19 was available? This paper experimentally investigates people's vaccination choices in the context of a nonlinear public good game. A "vaccination game" is defined in which costly commitments (vaccination) are required of a fraction of the population to reach the critical level needed for herd immunity, without which defectors are punished by the natural contagion of epidemics. Our experimental implementation of a vaccination game in a controlled laboratory setting reveals that endogenous epidemic punishment is a credible threat, resulting in voluntary vaccination to obtain herd immunity, for which the orthodox principle of positive externalities fails to account. The concave nature of the infection probability plays a key role in facilitating the elimination of an epidemic.

The Interplay of Public Intervention and Private Choices in Determining the Outcome of Vaccination Programmes

PLoS ONE, 2012

After a long period of stagnation, traditionally explained by the voluntary nature of the programme, a considerable increase in routine measles vaccine uptake has been recently observed in Italy after a set of public interventions aiming to promote MMR immunization, whilst retaining its voluntary aspect. To account for this take-off in coverage we propose a simple SIR transmission model with vaccination choice, where, unlike similar works, vaccinating behaviour spreads not only through the diffusion of ''private'' information spontaneously circulating among parents of children to be vaccinated, which we call imitation, but also through public information communicated by the public health authorities. We show that public intervention has a stabilising role which is able to reduce the strength of imitation-induced oscillations, to allow disease elimination, and to even make the disease-free equilibrium where everyone is vaccinated globally attractive. The available Italian data are used to evaluate the main behavioural parameters, showing that the proposed model seems to provide a much more plausible behavioural explanation of the observed take-off of uptake of vaccine against measles than models based on pure imitation alone.

Beyond Rational Decision-Making: Modelling the Influence of Cognitive Biases on the Dynamics of Vaccination Coverage

PLOS ONE, 2015

Theoretical studies predict that it is not possible to eradicate a disease under voluntary vaccination because of the emergence of non-vaccinating "free-riders" when vaccination coverage increases. A central tenet of this approach is that human behaviour follows an economic model of rational choice. Yet, empirical studies reveal that vaccination decisions do not necessarily maximize individual self-interest. Here we investigate the dynamics of vaccination coverage using an approach that dispenses with payoff maximization and assumes that risk perception results from the interaction between epidemiology and cognitive biases. We consider a behaviour-incidence model in which individuals perceive actual epidemiological risks as a function of their opinion of vaccination. As a result of confirmation bias, sceptical individuals (negative opinion) overestimate infection cost while pro-vaccines individuals (positive opinion) overestimate vaccination cost. We considered a feedback between individuals and their environment as individuals could change their opinion, and thus the way they perceive risks, as a function of both the epidemiology and the most common opinion in the population. For all parameter values investigated, the infection is never eradicated under voluntary vaccination. For moderately contagious diseases, oscillations in vaccination coverage emerge because individuals process epidemiological information differently depending on their opinion. Conformism does not generate oscillations but slows down the cultural response to epidemiological change. Failure to eradicate vaccine preventable disease emerges from the model because of cognitive biases that maintain heterogeneity in how people perceive risks. Thus, assumptions of economic rationality and payoff maximization are not mandatory for predicting commonly observed dynamics of vaccination coverage. This model shows that alternative notions of rationality, such as that of ecological rationality whereby individuals use simple cognitive heuristics, offer promising new avenues for modelling vaccination behaviour.

Vaccination, Herd Behavior, and Herd Immunity

Medical Decision Making, 2013

Background: During the 2009 outbreak of novel influenza AH1N1, insufficient data were available to adequately inform decision makers about benefits and risks of vaccination and disease. We hypothesized that individuals would opt to mimic their peers, having no better decision anchor. We used Game Theory, decision analysis, and transmission models to simulate the impact of subjective risks and preference estimates on vaccination behavior. Methods: We asked 95 students to provide estimates of risk and health state valuations with regard to AH1N1 infection, complications, and expectations of vaccine benefits and risks. These estimates were included in a sequential chain of models: a dynamic epidemic model, a decision tree, and a population-level model. Additionally, participants' intentions to vaccinate or not at varying vaccination rates were documented. Results: The model showed that at low vaccination rates, vaccination dominated. When vaccination rates increased above 78%, nonvaccination was the dominant strategy. We found that vaccination intentions did

How Rational is the Reluctance to be Vaccinated Against COVID-19? An Economic Approach

Journal of Insurance and Financial Management, 2021

This paper considers a static game in which a player makes a decision in the first moment of whether or not to be vaccinated against COVID-19 and then nature acts. In making the decision the player takes into consideration expected costs and benefits of being inoculated in terms of income. The relative speed with which the first vaccines have reached the market has caused some parts of the population to be concerned about the possible side effects of vaccination and, as a result, a part of the population is reluctant to take the vaccine. The papers finds that according to statistics on the pandemic’s evolution and certain assumptions about the likelihood of virus sequelae and vaccine side-effects, the decision to be vaccinated appears to be optimal. Low probability of contagion and a very low vaccine effectiveness rate are needed to make the decision to be vaccinated non-optimal.

The Impacts of Subsidy Policies on Vaccination Decisions in Contact Networks

2012

To motivate more people to participate in vaccination campaigns, various subsidy policies are often supplied by government and the health sectors. However, these external incentives may also alter the vaccination decisions of the broader public, and hence the choice of incentive needs to be carefully considered. Since human behavior and the networking-constrained interactions among individuals significantly impact the evolution of an epidemic, here we consider the voluntary vaccination on human contact networks. To this end, two categories of typical subsidy policies are considered: (1) under the free subsidy policy, the total amount of subsidy is distributed to a certain fraction of individual and who are vaccinated without personal cost, and (2) under the partial-offset subsidy policy, each vaccinated person is offset by a certain amount of subsidy. A vaccination decision model based on evolutionary game theory is established to study the effects of these different subsidy policies on disease control. Simulations suggest that, because the partial-offset subsidy policy encourages more people to take vaccination, its performance is significantly better than that of the free subsidy policy. However, an interesting phenomenon emerges in the partial-offset scenario: with limited amount of total subsidy, a moderate subsidy rate for each vaccinated individual can guarantee the group-optimal vaccination, leading to the maximal social benefits, while such an optimal phenomenon is not evident for the free subsidy scenario.

Social responsibility is the crucial factor in adopting early vaccination plans

medRxiv, 2020

Early vaccination of the general population is a very crucial aspect in the successful mitigation of highly infectious diseases, as it is the case of the SARS-CoV-2 pandemic. The perception of possible side-effects from early batches of vaccines, presumably under-tested, is often a hindering factor for people not in high-risk categories to opt-in for early vaccination. In this work, early vaccination is formulated under a game-theoretic view with preference ranking and expectation maximization, in order to explore the constraints and conditions under which individuals are keen to opt-in for getting vaccinated. Although simple preference ranking leads to purely non-cooperative / non-altruistic Nash equilibrium, stable cooperative strategies can emerge under simple constraints on the payoffs, specifically the individual cost from possible side-effects versus the collective gain for the community (`herd') when endorsing vaccination by default.