Synthesis and Characterization of Chitosan Coated Manganese Zinc Ferrite Nanoparticles as MRI Contrast Agents (original) (raw)
Related papers
Journal of Nanotechnology in Engineering and Medicine, 2014
Two different preparations of biocompatible magnetic nanoparticles (MNPs), both (MnFe 2 O 4 and Mn0.91Zn0.09Fe 2 O 4 ) coated with methoxy polyethylene glycol aldehyde (m-PEG-CHO) were prepared through coprecipitation method. The prepared powder was reanalyzed for material structure with an X-ray diffractometer (XRD) and for particle size using a transition electron microscope (TEM). Magnetic saturation (MS) and coercivity (HC) of the formed particles were examined by a vibrating sample magnetometer (VSM). Surface structure of the samples was characterized by Fourier transform infrared spectroscopy (FTIR). Biocompatible ferrofluids were intravenously injected into four rabbits. Then the magnetic resonance (MR) images of brain were obtained by magnetic resonance imaging (MRI) experiments before and after intravenous injection of ferrofluids. The MNPs demonstrate super paramagnetic behavior with a spinel structure measuring 30-40 nm in size. Doping of these magnetite nanoparticles with zinc resulted in decreases in crystallite size from 24.23 nm to 21.15 nm, the lattice parameter from 8.45 A˚to 8.43 A˚and the coercivity from 41.20 Oe to 13.07 Oe. On the other hand, saturation magnetization increased from 50.12 emu/g to 57.36 emu/g following zinc doping. Image exposure analysis revealed that the reduction of MR signal intensity for zincdoped magnetite nanoparticles was more than nondoped nanoparticles (shorter T 2 relaxation time) thereby making the images darker.
Journal of Nanotechnology in Engineering and Medicine, 2014
Two different preparations of biocompatible magnetic nanoparticles (MNPs), both (MnFe2O4 and Mn0.91Zn0.09Fe2O4) coated with methoxy polyethylene glycol aldehyde (m-PEG-CHO) were prepared through coprecipitation method. The prepared powder was reanalyzed for material structure with an X-ray diffractometer (XRD) and for particle size using a transition electron microscope (TEM). Magnetic saturation (MS) and coercivity (HC) of the formed particles were examined by a vibrating sample magnetometer (VSM). Surface structure of the samples was characterized by Fourier transform infrared spectroscopy (FTIR). Biocompatible ferrofluids were intravenously injected into four rabbits. Then the magnetic resonance (MR) images of brain were obtained by magnetic resonance imaging (MRI) experiments before and after intravenous injection of ferrofluids. The MNPs demonstrate super paramagnetic behavior with a spinel structure measuring 30–40 nm in size. Doping of these magnetite nanoparticles with zinc ...
International Journal of Molecular Sciences
The need for stable and well-defined magnetic nanoparticles is constantly increasing in biomedical applications; however, their preparation remains challenging. We used two different solvothermal methods (12 h reflux and a 4 min microwave, MW) to synthesize amine-functionalized zinc ferrite (ZnFe2O4-NH2) superparamagnetic nanoparticles. The morphological features of the two ferrite samples were the same, but the average particle size was slightly larger in the case of MW activation: 47 ± 14 nm (Refl.) vs. 63 ± 20 nm (MW). Phase identification measurements confirmed the exclusive presence of zinc ferrite with virtually the same magnetic properties. The Refl. samples had a zeta potential of −23.8 ± 4.4 mV, in contrast to the +7.6 ± 6.8 mV measured for the MW sample. To overcome stability problems in the colloidal phase, the ferrite nanoparticles were embedded in polyvinylpyrrolidone and could be easily redispersed in water. Two PVP-coated zinc ferrite samples were administered (1 mg/m...
Zinc–Nickel Ferrite Nanoparticles as a Contrast Agent in Magnetic Resonance Imaging
Applied Magnetic Resonance, 2016
Today, contrast agents are used to improve the sensitivity of magnetic resonance imaging (MRI) to detect pathologic structures. Ferrite nanoparticles are a class of superparamagnetic contrast agents in MRI. In this study, Zn 0.5 Ni 0.5 Fe 2 O 4 nanoparticles were synthesized via precipitation method and coated with dextrin to increase the solubility and biocompatibility. The morphology, size, structure, and magnetic properties of nanoparticles were investigated. These nanoparticles have superparamagnetic property with a narrow size distribution with a mean diameter of about 20.5 ± 3.2 nm. MRI study using phantom agar shows that these nanoparticles can be used as an effective contrast agent for T 2 and T à 2 -weighted imaging. The relaxivities of r 2 and r à 2 are 8.78 and 82.08 s -1 mmol L -1 , respectively. From these findings, it is possible that dextrin-coated Zn 0.5 Ni 0.5 Fe 2 O 4 nanoparticles can be used as a good negative contrast agent in MRI.
Cobalt Zinc Ferrite Nanoparticles as a Potential Magnetic Resonance Imaging Agent: An In vitro Study
Avicenna journal of medical biotechnology
Magnetic Nanoparticles (MNP) have been used for contrast enhancement in Magnetic Resonance Imaging (MRI). In recent years, research on the use of ferrite nanoparticles in T2 contrast agents has shown a great potential application in MR imaging. In this work, Co0.5Zn0.5Fe2O4 and Co0.5Zn0.5Fe2O4-DMSA magnetic nanoparticles, CZF-MNPs and CZF-MNPs-DMSA, were investigated as MR imaging contrast agents. Cobalt zinc ferrite nanoparticles and their suitable coating, DMSA, were investigated under in vitro condition. Human prostate cancer cell lines (DU145 and PC3) with bare (uncoated) and coated magnetic nanoparticles were investigated as nano-contrast MR imaging agents. Using T2-weighted MR images identified that signal intensity of bare and coated MNPs was enhanced with increasing concentration of MNPs in water. The values of 1/T2 relaxivity (r2) for bare and coated MNPs were found to be 88.46 and 28.80 (mM (-1) s(-1)), respectively. The results show that bare and coated MNPs are suitable ...
Zinc ferrite nanoparticles as MRI contrast agents
Chemical Communications, 2008
Mixed spinel hydrophobic Zn x Fe 1Àx OÁFe 2 O 3 (up to x = 0.34) nanoparticles encapsulated in polymeric micelles exhibited increased T 2 relaxivity and sensitivity of detection over clinically used Feridex s .
Chitosan-stabilized iron oxide nanoparticles for magnetic resonance imaging
Journal of Magnetism and Magnetic Materials, 2018
The iron oxide nanoparticles were synthesized by the co-precipitation method and consequently stabilized by a chitosan coating. The characterization of the chitosan modified nanoparticles was performed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), dynamic light scattering (DLS), SQUID magnetometer and MRI analysis. The particle size and ζ-potential measurement, the measured hydrodynamic diameter of chitosan modified magnetic nanoparticles was equal to 136.1 nm, while the ζpotential is + 48 mV. The superparamagnetic behaviour of both unmodified and chitosan modified Fe3O4 nanoparticles at room temperature was confirmed using a SQUID magnetometer. Finally, the relaxation times (T1 and T2) were measured by MRI. From the result of magnetic resonance imaging (MRI) analysis, the relaxation rate (R) and relaxivity (r) have been calculated: = 0.713 mM-1 s-1 , = 238.16 mM-1 s-1 and = 276.1 mM-1 s-1. An acquired high r 2 /r 1 ratio (334) indicates that the prepared nanoparticles have a significant prevailing effect on the transversal relaxation time (T 2) in comparison to the longitudinal relaxation time (T 1). These results demonstrate the potential usefulness of chitosan-stabilized iron oxide nanoparticles as a contrast agent for MRI.
Carbohydrate Polymers, 2014
Super-paramagnetic iron oxide nanoparticles (SPIONPs) were encapsulated at various concentrations within chitosan-triphosphate (SPIONPs-CS) nanoparticles using an ionotropic gelation method. The encapsulation of SPIONPs within CS nanoparticles enhanced their dispersion ability in aqueous solution, with all particles being lower than 130 nm in size and having highly positive surface charge. The SPIONPs-CS nanoparticles exhibited crystalline structure and super-paramagnetic behavior, as seen in non-encapsulated SPIONPs. The morphology of SPIONPs-CS nanoparticles showed that they almost spherical in shape. The effect of phantom environments (culture medium and 3% agar solution) on either T 1 or T 2 weighted MRI was investigated using a clinical 1.5 T MRI scanner. The results revealed that 3% agar solution showed relaxation values higher than the culture medium, leading to a significant decrease in the MR image intensity. Our results demonstrated that the SPIONPs-CS nanoparticles can be applied as tissue-specific MRI contrast agents.
Coatings
Magnetic resonance imaging (MRI) is an imaging technique that is widely used for the identification of internal organs, and for the medical diagnosis of tumors and cancer in the body. In general, gadolinium is used as a contrast agent to enhance image contrasting in MRI. In this study, chitosan-coated Co0.5Zn0.5Fe2O4 nanoparticles were synthesized using a co-precipitation method with a calcination temperature of 500 °C. The nanoparticles were then coated with chitosan and treated under an external magnetic field of 400 mT. X-ray diffractometer results showed that the chitosan-coated Co0.5Zn0.5Fe2O4 nanoparticles had a pure phase of Co0.5Zn0.5Fe2O4 at the (3 1 1) plane, with an average particle size of 26 nm. The presence of chitosan on the Co0.5Zn0.5Fe2O4 nanoparticles was confirmed by Fourier transform infrared spectroscopy, which showed the primary amine and secondary amine functional groups of chitosan. Here, coating the nanoparticle with chitosan not only prevented nanoparticle ...
Journal of Magnetism and Magnetic Materials, 2009
Previous studies have shown that magnetic nanoparticles possess great potential for various in vivo applications such as magnetic resonance imaging contrast enhancement, tissue repair, cancer treatment agents, and controlled drug delivery. Many of these applications require that magnetic nanoparticles be colloidally stable in biological media. The goal of this study was to obtain a magnetic fluid produced by the colloidal suspension of manganese/zinc ferrite (MZF) nanoparticles that could be stably dispersed in aqueous solution throughout the range of physiological pH and ionic strength. These superparamagnetic nanoparticles were stabilized through steric repulsion by coating with biologically compatible carboxymethyl dextran (CMDx). Samples of the resultant magnetic fluid were analyzed using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), X-ray diffraction (XRD), zeta potential measurements, dynamic light scattering, transmission electron microscopy (TEM), and SQUID magnetometry. Results show that we obtained superparamagnetic metal-oxide crystals with composition of Mn 0.24 Zn 0.76 Fe 2 O 4 . Cell viability measurements show the material is non-toxic to MCF-7 and CaCo-2 cell lines at concentrations of up to 7.5 mg/mL of particle fraction for contact time of up to 48 h.