Redundancy in B Cell Developmental Pathways: c-Cbl Inactivation Rescues Early B Cell Development through a B Cell Linker Protein-Independent Pathway (original) (raw)

Deficiency in the adaptor protein B cell linker protein (BLNK) creates a significant yet incomplete blockade in B cell development, hinting at alternative differentiation pathways. The study explores the role of c-Cbl, another adaptor protein that negatively regulates B cell receptor (BCR) signaling, and demonstrates that its inactivation rescues early B cell development in BLNK-deficient models via a BLNK-independent pathway. Findings indicate that c-Cbl inactivation leads to crucial enhancements in developmental transitions, signaling events, and overall effective early B cell differentiation.