Correlation between Vitamin D Deficiencyand Rheumatoid Arthritis Patients. (original) (raw)
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Background: Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease of unknown etiology affecting approximately 1% of the world population,0.75% in India and 0.2% in Manipur. The hallmark swelling, bony erosions and synovial thickening reflect the underlying inflammatory and auto immune processes of RA.Deficiency of vitamin D is studied for its involvement in the pathogenesis of RA, as well as for correlating with disease activity of RA.Therefore,we conducted this study to derive the correlation between serum vitamin D level and RA disease activity specifically from the cohort population of Manipur,India. Methods:Rheumatoid arthritis patients who were attending Medicine OPD,Rheumatology OPD or admitted inthe General Medicine wards at Regional Institute of Medical Sciences (RIMS), Imphal, Manipur from 2017 to 2019. Total 52 diagnosed cases of RA(2010 ACR-EULAR criteria) were included andserum vitamin D and other related blood investigations were studied. Results:Vitamin D deficiency was found in 17 patients (32.7 %).20 patients had vitamin D insufficiency and remaining 15 patients have normal serum vitamin D level.According to DAS-28 ESR scoring system, 38(73.1%) patients fall under moderate to severe disease activity and 16 of them had vitamin D deficiency, while 3 of them had normal vitamin D level. Conclusion:There was significant association between vitamin D deficiency and disease activitysuggesting Vitamin D deficiency as an independent risk factor for disease severity in RA. Therefore, all RA patients must be given vitamin D supplementation in order to reduce the severity of the disease process.
Assessment of vitamin D status in rheumatoid arthritis patients
International journal of health sciences
Background: Vitamin D is a secosteroid hormone involved in bone and calcium metabolism. It is involved in the regulation of calcium homeostasis, as it regulates calcium absorption from the gastrointestinal system. The present study was conducted to assess vitamin D status in RA patients. Materials & Methods: 112 Rheumatoid arthritis patients of both genders were put in group I. Healthy subjects were also enrolled and put in group II. Disease activity score of RA patients was calculated. Disease severity was assessed according to the value of DAS28 score as follows- Remission: DAS28 ≤2.6 Low disease activity: 2.6 5.1. 25 (OH)-Vitamin D Xpress ELISA Kit was used for the quantitative measurement of Vitamin D3 {25 (OH)-D3} in serum. Results: Group I had 62 males and 50 females and group II had 70 males and 42 females. Disease activity was remission, low, moderate and high with mean serum calcium level (mg/dl) as 8.92, 8.34, 8.22 and 8.01 and vitamin D (mg/dl) as 35.6, 31.4, 22.3 and 14....
A study to evaluate the vitamin D status in rheumatoid arthritis patients
International Journal of Clinical Biochemistry and Research, 2017
Introduction: Vitamin D deficiency has been shown to be associated with autoimmune diseases, which is a controversial finding in various previous studies. Moreover there are limited studies done on serum vitamin D and its association with rheumatoid arthritis in Indian population. Therefore the present study was designed to study the level of vitamin D in patients with rheumatoid arthritis and to compare it with healthy controls. Materials and Methods: The study included 40 patients diagnosed for rheumatoid arthritis (RA) and 40 age and sex matched healthy controls who were willing to participate in the study from the department of orthopaedics and General medicine. After obtaining the written informed consent from all the participants, 2 ml of blood was collected in a plain vacutainer for the estimation of vitamin D by chemi-luminescent method. Results: The cut off values of 25-OH vitamin D level, being 30ng/ml as normal. There was neither any statistical difference in the vitamin ...
IOSR Journals , 2019
Introduction: Rheumatoid arthritis is an immune-mediated disease, mainly driven by Th1 cells. Prevalence of RA is approximately 0.8% of population (range 0.13-1.2%). Overall prevalence of RA is three times higher in women than in men Vitamin D may have a role in Rheumatoid arthritis because it suppresses Th1 cells which are a part of adaptive immunity. Data obtained from animal models show that the VDR ligand along with other factors may control the development of RA 5 .Due to possible role of vitamin D in development of RA and its severity, we conducted this study to find out correlation between rheumatoid arthritis disease activity and serum Vitamin D level .Material and methods: Hospital based case control type of analytical study of 80 cases of Rheumatoid arthritis and 80 controls studied based on detailed history, examination, blood investigations,DAS 28 score.Results: In our study there was significant negative correlation between disease activity measured by DAS-28 in RA and serum 25(OH) Vitamin D level (p<0.05) Conclusion: The result of our study showed that In Rheumatoid arthritis, disease activity measured by DAS-28 is inversely related to Vitamin D level. So timely vitamin d supplementation to patients can reduce inflammatory burden.