The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies (original) (raw)

Factors affecting the morphology of benzoyl peroxide microsponges

Micron, 2007

Benzoyl peroxide (BPO) is primarily used in the treatment of mild to moderate acne. However, its application is associated with skin irritation. It has been shown that encapsulation and controlled release of BPO could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The aim of the present investigation was to design and formulate an appropriate encapsulated form of BPO, using microsponge technology, and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Benzoyl peroxide particles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethane into a stirred aqueous phase containing polyvinyl alcohol (PVA). Different concentrations of BPO microsponges were incorporated in lotion formulations and the drug release from these formulations were studied. The SEM micrographs of the BPO microsponges enabled measurement of their size and showed that they were spherical and porous. Results showed that the morphology and particle size of microsponges were affected by drug:polymer ratio, stirring rate and the amount of emulsifier used. The results obtained also showed that an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from the microsponges. The release data showed that the highest and the lowest release rates were obtained from lotions containing plain BPO particles and BPO microsponges with the drug:polymer ratio of 13:1, respectively. The kinetics of release study showed that the release data followed Peppas model and the main mechanism of drug release from BPO microsponges was diffusion.

Drug Delivery from Microsponges: A Review Article

2021

Microsponges are micro-porous particles, used mainly for topical and recently for oral administration. Microsponges have many advantages which make it a versatile drug delivery system. Microsponges can suspended or entrap a wide variety of substances and then be incorporated into a formulated product such as a gel, cream, liquid, or powder. Moreover, they may enhance stability, reduce side effects and modify drug release related to its porous structure which allows the active ingredient to sustain over time. This article aims to provide details about microsponges including the method of preparation, characterization, mechanism of drug release from microsponges, different formulation, and process factors, and a few applications about microsponges that are either proven or under research. Besides, microsponges improve stability, increase elegance, and enhance formulation flexibility. Previous studies were done and confirmed that microsponges are non-irritant, non-allergenic, non-mutag...

Microsponges: An Approach to Novel Drug Delivery System-A Review

2015

Microsponges, the drug release technology has become more spirited and rapidly on the rise. Different drug delivery systems are being incorporated to optimize the efficiency and cost-effectiveness of the rehabilitation. In malevolence of presence of these technologies the drug delivery systems are unsuccessful to reach the systemic circulation in adequate amounts in control manner in few cases like Peptides and proteins. Conventional topical formulations have also many problems, such as producing a highly concentrated layer of active ingredient resulting irritation and allergic reactions etc. To control the delivery rate of active agents to a encoded site in human body has been one of the major challenges for drug industry. This review article focus on the Novel approaches to product formulation incorporating Microsponges technology may offers better entrapment of ingredients, reduced side effects, increased elegance, and enhanced formulation flexibility.

JOURNAL OF DRUG DELIVERY RESEARCH MICROSPONGE:A NOVEL TOPICAL DRUG DELIVERY SYSTEM

Microsponge technology is novel technique generally used for transfer of active drug into the skin. It is a controlled release secretion system also helps to reduce systemic exposure and minimize local cutaneous reactions to active drugs. Microsponges used to control delivery of drug at specific predetermined site in body. The Microsponge Delivery System (MDS) is a unique technology for the controlled release of topical agents and consists of macroporous beads, typically 10-25 microns in diameter, loaded with active agent. Microsponges can entrapped various types of drug and incorporated in formulation such as cream, powder, gels and lotions. When applied to the skin; the microsponge releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH, etc) also microsponges are taken orally route. Microsponge technology offers entrapment of active drug ingredients and is used in to reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. The microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microsponges also inhibit the various problems than other formulation problem such as need of regular dosing, drug reaction; incompatibility with environmental condition also easily stop the treatment and no need of special knowledge. The present review introduces Microsponge technology along with its method of preparation, characterization, advantages and release mechanism of MDS. INTRODUCTION Various systems were developed for systemic drugs under the class of trans-dermal delivery system (TDS) using the skin as portal of entry. Topical drugs while applying having many problems such as ointments, which are often aesthetically unappealing, greasiness, stickiness etc. that often results into lack of patient compliance. Also gels, powders, lotion has low time of contact with skin therefore these vehicles require high concentrations of active agents for effective therapy because of their low efficiency of delivery system no longer drug can be absorb form skin. This problem can be recovered by the microsponges. Microsponges require low drug content but having the longtime of contact with skin. Resulting into no irritation and allergic reactions are observed in some patient. A Microsponge Delivery System (MDS) is patented, highly cross-linked, porous, polymeric microspheres that can entrap wide range of actives and then release them with desired rate[1].This system is useful for the improvement of performance of topically applied drugs. It is a unique technology for the controlled release of topical agents and consists of microporous beads, typically 10-25 microns in diameter, loaded with active agent. Their high degree of cross-linking results in particles that are insoluble, inert and of sufficient strength to stand up to the high shear commonly used in manufacturing of creams, gels, lotions, and powders. Their characteristic feature is the capacity to adsorb or " load " a high degree of active materials into the particle and on to its surface[2].Microsponges should be

Formulation and Evaluation of Microsponges Gel for Topical Use

2017

The purpose behind undertaking this project was to formulate and evaluate gel containing microsponges of Clobetasol Propionate (CP) to deliver CP in a perennial manner for far-reaching time period to reduce application frequency, hypersensitive reactions and to improve safety than conventional formulation. Quasi-emulsion solvent diffusion method was employed using Ethyl Cellulose as a polymer and microsponges with varied drug–polymer ratios were prepared. For optimization purposes, diverse factors affecting microsponges physical properties were investigated. Microsponges were characterized by SEM, FT-IR, and for particle size analysis and evaluated for drug content and drug loading, morphology and in-vitro release study as well. No chemical interactions were found between drug and polymer used which can be seen in results of compatibility studies. Drug-polymer ratio manifested luminary effect on production yield, drug content and drug loading efficiency, drug release and particle si...

Microsponge Technology as a Novel Approach for Topical Drug Delivery: An Acquainted Review

Microsponge drug delivery system offers a promising opportunities in multiple pharmaceutical implementations as it has distinctive characteristics such as enhanced product quality and elegance, expanded release, enhanced drug release profile, decreased discomfort, enhanced physical, chemical, and thermal stability, making it easy to develop novel product form. These are modern drug delivery systems capable of entrapping higher concentration of drugs due to networks or pores that interconnect. They can be prepared primarily by two techniques based on liquid suspension polymerization and solvent diffusion depending upon the physicochemical properties of the drug to be loaded. Microsponge delivery system was initially designed for the delivery of drugs topically or through the skin. Nowadays, Microsponges are often used for topical delivery carriers for anti-fungal, anti-inflammatory, anti-ulcer therapy and constitute major components of variety of dermatological and cosmetic products such as creams, gel, lotion etc. Microsponges can also be used for oral delivery of drugs by using water soluble and bio-erodible polymers. Microsponges have a bright future in the coming era in various pharmaceutical applications which make them superior to the microcarriers of today. The present review introduces about various formulation approaches, characterization, applications, present market scenario, patents and future prospects on microsponge technology.

Microsponge Drug Delivery System -A Review

PENSEE, 2020

Recent research on idealizing drug delivery system which is progressing at a prodigious rate and aims at development of drug delivery system (DDS), with maximum therapeutic advantages of drug delivery, thus resulting in safe and effective management of disease.[1] Micro sponges are polymeric delivery system composed of porous microspheres. They are tiny sponge-like spherical particle with a large porous surface. Microsponge system offers entrapment of ingredient and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. Micro-sponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. Micro-sponge consists of microporous beads loaded with active agent. When applied to the skin, the Microsponge releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH etc.) that are used mostly for topical and recently for oral administration Microsponge are porous, polymeric microspheres that are mostly used for prolonged topical administration. Microsponge Systems are based on microscopic, polymerbased microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. The present review elaborates about the multifunctional Microsponge technology including its preparation, characterization, evaluation methods along with recent research and future potential.