A drug release study from hydroxypropylmethylcellulose (HPMC) matrices using QSPR modeling (original) (raw)
Related papers
PURPOSE: The present work reports an attempt was to formulate matrix systems for oral sustained release drug delivery systems using diverse grades of hydroxypropyl methylcellulose (Methocel K4M, K15M, K100M and K100LV), in order to investigate the effect of various grades of these polymer on release mechanism from matrix tablets. Diclofenac Sodium was used as a model drug to evaluate its release characteristics from different matrices. METHODS: HPMC matrix tablets of Diclofenac Sodium using HPMC (methocel K100LV K4M, K15M, K100M CR) lactose were prepared by direct compression process. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml 0.1 N HCl, and phosphate buffer. Drug release was analyzed according to their kinetic models. A One way analysis of variance (ANOVA) was used to interpret the result. RESULTS: Statistically significant differences were found among the drug release profile from different matrices. At a fixed polymer level, drug release from the higher viscosity grades (K100M) was slower as compared to the lower viscosity grades (K100LV). The best-fit release kinetics was achieved with the zeroorder plot, followed by the Higuchi and Korsmeyer equations. Two formulations showed drug release is more controlled. The data obtained proved that the formulations are useful for a sustained release of Diclofenac. CONCLUSIONS: From these formulations corresponded more controlled of the drug release by the higher viscosity grade of HPMC. The release of the model drug from these HPMC matrix tablets was prolonged; as a result, an oral release dosage form to avoid the gastrointestinal adverse effects was achieved.
Evaluation of ethylcellulose as matrices for controlled release drug delivery
Pakistan journal of pharmaceutical sciences, 2005
As the efficiency of a matrix forming polymer in sustaining drug release is a multiple function of physico-chemical nature of the active ingredient and pH of the surrounding environment, the study was undertaken to evaluate the effect of pH of dissolution media on the release profile of three drug molecules with diversified physico-chemical properties. Matrix tablets of diclofenac sodium, theophylline and diltiazem HCl were prepared using ethylcellulose as the matrix forming agent. The drug dissolution behavior of the matrix tablets were studied over 10 hours in buffer media of pH 1.2, 4.5 and 6.8. Elevation of pH of the dissolution medium increased the rate and extent of diclofenac release. However, for diltiazem HCl, increasing the pH showed the reverse pattern. Theophylline release, on the other hand, seemed to be unaffected by the pH of the dissolution media. This can be correlated with the physico-chemical characteristics of the drugs. Effect of compression force on drug releas...