Vitamin D Inadequacy Is Associated with Significant Coronary Artery Stenosis in a Community-Based Elderly Cohort: The Korean Longitudinal Study on Health and Aging (original) (raw)
Related papers
Archives of Medical Science, 2016
Introduction: A deficiency of 25-hydroxyvitamin D (25(OH)D) (the standard biomarker for vitamin D status) can have multiple impacts on the cardiovascular system. The aim of the study was to assess of the influence of 25(OH)D on severity of coronary atherosclerosis and lipid profile. Material and methods: The study involved prospectively 637 patients subject to coronary catheterization. The stage of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study score (CASSS). Plasma concentration of 25(OH)D was measured using an electrochemiluminescent immunoassay. The levels of total cholesterol (TC), high-density cholesterol (HDL-C) and triglycerides (TG) were measured using the enzymatic method, and the concentration of low-density cholesterol (LDL-C) was calculated with the Friedewald equation. Results: The average level of 25(OH)D was 15.85 ng/ml. A higher level of 25(OH)D was observed in men (16.28 ng/ml vs. 15.1 ng/ml; p = 0.027). The study did not reveal any significant correlation between the level of 25(OH)D and severity of coronary atherosclerosis. It was observed however that the increase of 25(OH)D level results in an increased number of patients without significant lesions in the coronary arteries. In the whole group of women and men in the age group of 70-80 years an inverse relationship was observed between the level of 25(OH) and the severity of coronary atherosclerosis. The whole study group showed a statistically significant inverse correlation of the 25(OH)D level with TC (p = 0.0057), LDL-C (p = 0.00037) and TG (p = 0.00017). Conclusions: Women and men over 70 years showed an inverse correlation of the 25(OH)D level and the stage of coronary atherosclerosis. Deficiency of 25(OH)D affects the levels of TC, LDL-C and TG.
Vitamin D deficiency and coronary artery disease: A review of the evidence
American Heart Journal, 2014
BACKGROUND: Several factors such as hyperlipidemia, diabetes and hypertension have a determining role in cardiovascular disease. In recent years, the effect of vitamin D deficiency on cardiovascular disease has been emphasized. This study compares vitamin D deficiency in coronary heart disease patients with the control group. METHODS: In a cross-sectional study, 25hydroxycholecalciferol level was compared in 119 individuals including 57 people with confirmed coronary heart disease and 62 healthy people. 25-hydroxyvitamin D [25(OH)D] was assessed using standard protocol. The level of 25(OH)D under 20 ng/dl was determined as cutoff point. RESULTS: The calculated odds ratio was 3.9 (95% confidence interval 2.6-5.5). Vitamin D deficiency significantly different between patients and the control group (p = 0.01). Of 37 (31%) individuals having vitamin D deficiency, 36 (97.3%) had coronary artery disease and from 57 patients with coronary artery disease 36 (63.2%) had vitamin D deficiency. CONCLUSIONS: Vitamin D deficiency is a relatively common disorder. Risk of cardiovascular disease in people with vitamin D deficiency is almost four times of those with normal levels of vitamin D. To confirm the casual relationship between vitamin D and cardiovascular disease, clinical trial studies are suggested.
Vitamin D deficiency and coronary artery disease
Journal of Research in Medical Sciences, 2012
BACKGROUND: Several factors such as hyperlipidemia, diabetes and hypertension have a determining role in cardiovascular disease. In recent years, the effect of vitamin D deficiency on cardiovascular disease has been emphasized. This study compares vitamin D deficiency in coronary heart disease patients with the control group. METHODS: In a cross-sectional study, 25hydroxycholecalciferol level was compared in 119 individuals including 57 people with confirmed coronary heart disease and 62 healthy people. 25-hydroxyvitamin D [25(OH)D] was assessed using standard protocol. The level of 25(OH)D under 20 ng/dl was determined as cutoff point. RESULTS: The calculated odds ratio was 3.9 (95% confidence interval 2.6-5.5). Vitamin D deficiency significantly different between patients and the control group (p = 0.01). Of 37 (31%) individuals having vitamin D deficiency, 36 (97.3%) had coronary artery disease and from 57 patients with coronary artery disease 36 (63.2%) had vitamin D deficiency. CONCLUSIONS: Vitamin D deficiency is a relatively common disorder. Risk of cardiovascular disease in people with vitamin D deficiency is almost four times of those with normal levels of vitamin D. To confirm the casual relationship between vitamin D and cardiovascular disease, clinical trial studies are suggested.
Association of vitamin D deficiency and coronary artery disease with cardiovascular risk factors
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012
Vitamin D deficiency is a prevalent condition in many countries. The aim of this study is to elucidate whether deficient vitamin D status is associated with coronary artery disease considering cardiovascular risk factors. We measured 25 (OH) D serum levels in 57 patients that were diagnosed with coronary artery disease upon coronary angiography and 62 individuals in the control group who were matched for age and sex with the patients and examined the association between serum 25 (OH) D and coronary artery disease with regard to cardiovascular risk factors. The odds ratio of being affected by coronary artery disease in individuals with vitamin D deficiency (25 (OH) D < 30 ng/ml) was 5.8 (1.77 - 18.94) after adjustment with cardiovascular risk factors, i.e., blood pressure, diabetes, smoking, obesity, physical activity and high blood cholesterol in comparison with the control group. Low levels of 25 (OH) D are associated with prevalent coronary artery disease independent of cardiov...
Correlation of vitamin D level and severity of coronary artery disease
Biomedicine
Introduction and Aim: Cardiovascular diseases are the leading cause of death worldwide. The prevalence of cardiovascular disease in India is continuously on the rise owing to the socioeconomic changes the country is undergoing. In order to minimise the mortality due to cardiovascular disease, early detection and control of modifiable risk factors is of utmost importance. We evaluated the correlation of vitamin D deficiency, one such possible modifiable risk factor, and the severity of CAD in patients at a hospital in Southern Karnataka. Unfortunately, relevant data regarding vitamin D deficiency in coronary artery disease pertaining to the Indian subcontinent is scarce. Thus, the results of our study can provide further evidence for the potential therapeutic benefit of Vitamin D in patients with cardiovascular risk factors, which in the long run can significantly reduce the morbidity and mortality of CAD. Materials and Methods: A case-control study with 142 subjects was conducte...
Associations between vitamin D and cardiovascular outcomes; Tehran Lipid and Glucose Study
Atherosclerosis, 2011
Background: Vitamin D status seems to have an association with cardiometabolic risk factors and its deficiency may negatively affect the cardiovascular outcomes. The aim of this study was to determine the possible association between vitamin D status and cardiovascular outcomes. Method: We performed a nested case control study within the Tehran Lipid and Glucose Study (TLGS), which followed a representative sample of Tehranian adults. A total of 251 matched pairs, aged > 30 years, were selected. Cases were TLGS individuals that were free of cardiovascular disease (CVD) at the beginning of study and developed CVD during assessments of 5.7 year follow up. Each case was matched by age, sex and the month of entry to study with a randomly selected control (risk-set sampling). Prespecified cut points were used to characterize varying degrees of 25-OH D deficiency (<10, between 10 and 14.9, and ≥15 ng/ml). Conditional logistic regression was used to investigate the association between 25-OH-D concentration and the incident cardiovascular outcomes. Results: The mean age of participants was 56.84 ± 11.17 years and 244 (48.6%) were women. The median (IQ: 25-75) of serum 25-OH-D was 14.1 ng/ml (9.6-29 ng/ml) and 306 (61%) of participants had serum 25-OH-D < 15 g/ml. Median serum 25-OH-D was lower in cases (12.5 vs. 18.1, P < 0.001). After adjustment for potential confounders, the odds ratio of serum 25-OH-D < 10 ng/ml for having CVD outcomes was 2.90 compared with 25-OH-D ≥ 15 (95% confidence interval (CI): 1.67-5.12, P < 0.001). Conclusion: Our results indicate that serum 25-OH-D concentration has an independent association with cardiovascular outcomes in adult Tehranians.
Association of vitamin D deficiency and premature coronary artery disease
Caspian Journal of Internal Medicine, 2019
Background: Evidence suggests hypovitaminosis D is associated with increased risk of coronary artery disease (CAD) and its extent and related risk factors. However, some investigations have produced contrary results. Therefore, we aimed to evaluate the association between serum vitamin D levels and the severity of premature coronary artery involvement. Methods: This randomized prospective, case-control study was conducted in Babol from April 2013 to June 2017. We collected the demographic data and measured serum 25-OH-D levels of 294 patients (age≤50 years) diagnosed with CAD with coronary angiography as case group as well as 438 age and sex-matched controls. CAD severity was assessed using the Gensini score. Statistical analyses were used to assess the associations and p<0.05 was considered as significant. Results: The mean serum level of 25-OH-D was 13.12±11.13 and 18.28±8.34 in case and control groups, respectively (P=0.036). In the case group, mean serum vitamin D levels were significantly lower among hypertensives (P=0.018), those with a family history of CVD (P=0.016) and those who used aspirin (P=0.036). The mean Gensini score of patients in the case group was 45.02±23.62 and was higher among men (P=0.022). There was a weak significant correlation between the serum vitamin D levels and the Gensini score (P=0.001 & R=-0.543). The mean Gensini score was not significantly different between patients with deficient (47.02±22.78), insufficient (26.0±21.72) and sufficient (39.0±43.84) vitamin D levels (P>0.05). Conclusion: The results showed that the lower levels of vitamin D is associated with increased risk and extent of coronary artery involvement as well as some of the risk factors of CAD, including male gender, hypertension and positive family history for CVD.
Nutrition research and practice, 2012
Vitamin D deficiency is a risk factor for metabolic syndromes. We examined whether vitamin D deficiency altered the prevalence of cardiovascular disease (CVD) in older Koreans. Cross-sectional analysis of data from the Korean National Health and Nutrition Examination Survey IV 2008-2009 was used to examine the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of CVD in a representative population-based sample of 5,559 men and women aged ≥ 50 years. CVD was defined as angina pectoris, myocardial infarction, or stroke. The prevalence of CVD (7.0%) in the older Korean population was lower than that in the older US population, although average serum 25(OH)D levels were much lower in the Korean population. Additionally, serum 25(OH)D levels did not differ significantly between the CVD and non-CVD groups. However, subjects in the lowest category (< 25 nmol/l) of serum 25(OH)D level had the greatest prevalence of CVD, about two-fold higher than subjects i...
Vitamin D Status and Cardiovascular Health: A 2009 Update~!2009-10-29~!2009-12-25~!2010-04-08~!
The Open Clinical Chemistry Journal, 2010
Vitamin D has long been known to be vital to bone health. More recently, vitamin D has been shown to play a role in the risk of malignancy, infection, autoimmune disease, renal disease, and cardiovascular disease (CVD) including its associated risk factors of diabetes and hypertension. Within the umbrella of cardiovascular disorders, low vitamin D levels have been specifically linked to increased risk of congestive heart failure, left ventricular hypertrophy, peripheral arterial disease, subclinical vascular disease, myocardial infarction, stroke, and mortality -associations that remain even after traditional risk factors and lifestyle factors are taken into account. However, a direct causal relationship between 25(OH)D deficiency and the risk of CVD has not been completely established.