Pharmaceutical Evaluation of Procedures for Preparation of Unani Formulation " Roghan Baiza-e-Murgh " and its Physicochemical Analysis (original) (raw)
Related papers
Quality Standard of Safoof razyanaj: A Unani Polyherbal Powder Formulation
Journal of Young Pharmacists, 2019
Objectives: Safoof razyanaj (SR) a Unani polyherbal powder formulation used in dyspepsia, distension of stomach and anorexia. Standardization data of SR. by using scientific analytical procedures was established. Methods: Cleaned and dried powder of plant drug was prepared as per the method described in Unani Pharmacopeia of India (UPI). SR formulation was evaluated using physicochemical tests: powder characterization, extractive value, alcohol and water-soluble matter, Ash value, LOD at 105°C, pH and HPTLC fingerprinting. Results: SR color was light brown, aromatic and sweetish in taste. Physicochemical parameters expressed as mean values of the three readings showed loss of weight on drying, total ash, acid insoluble ash and watersoluble ash as 4.62 ± 0.10, 4.95 ± 0.05, 1.83 ± 0.03 and 2.10 ± 0.03 respectively. The Bulk density, tapped density, angle of repose, Hauser's ratio and compressibility index were 0.46 ± 0.01, 0.56 ± 0.00, 35.62 ± 0.45, 1.23 ± 0.00 and 19.24 ± 0.59 respectively, pH of 1% and 10% solution were 4.78 ± 0.03 and 5.08±0.02 respectively. Extractive values in petroleum ether, benzene and ethyl alcohol by successive extraction method were 11.24 ± 0.14, 2.08 ± 0.04 and 6.73 ± 0.10 respectively. Extractive values in petroleum ether, benzene, ethyl alcohol and water by non-successive extraction method were 11.24 ± 0.14, 15.44 ± 0.24, 32.20 ± 0.13 and 34.28 ± 0.18 respectively. Qualitative analysis showed presence of alkaloid, tannin, terpenoid, protein, carbohydrate, phenol, glycoside, flavonoid and saponin. HPTLC fingerprinting data of SR in methanolic extract and mobile phase toluene: ethyl acetate: formic acid (5:4:1) was set in. Conclusion: Standardization data of SR was obtained.
QUALITY ANALYSIS OF TRADITIONAL UNANI FORMULATION DAWA-UL-KURKUM
ECB, 2023
Proper identification & standardization is mandatory to ensure the therapeutic efficacy of herbal drugs used for health ailments. Dawa-ul-Kurkum (DK) is an important Unani formulation that has been commonly used in the treatment of liver dysfunction, anorexia, ascites, and abdominal pain. This study is aimed to formulate standard manufacturing procedures for DK and to develop its organoleptic, physicochemical, and TLC standards. Dawaul-Kurkum is a semi-solid honey-based compound formulation that contains seven main ingredients. An inhouse formulation was prepared and standardized in accordance with the National Formulary of Unani medicine (NFUM). The finished product, DK, was analysed for organoleptic, physicochemical properties, TLC& HPTLC. Standardization of DK was achieved by organoleptic study and physicochemical parameters such as loss on drying, extractive values, ash value, total reducing sugars, and heavy metal study. Physicochemical values could be used to establish and formulate procedures for standardization and quality control of Dawa-ul-Kurkum. Total fungal and bacterial counts were found to be within the permissible limit. Heavy metals like arsenic, mercury, lead, and cadmium was also found to be in permissible quantities. This study helps in determining the quality and purity of Dawa-ul-Kurkum and may serve as a standard reference for developing standard operating procedures for the quality control analysis of Dawa-ul-Kurkum.
Analytical Study of Compound Unani Drug Habb-e-Mudir
Hamdard Medicus, 2011
II o li c The drugs used in Unani Medicine consist of materials from plant, animal and mineral origin that are either used si ngle or in combination with other drugs as poly-pharmaceuticals. .F.. flabb-e-Mudir is a poly-ingredient formulation compri sing Sibr (Aloe species), Zafran (Crocus sativus) and Hira Kasees Bufo (Ferrous Sulphate), in the ratio of 2: I : I (NFUM I) indicated for the treatment of ameno rrhoea. Present study is aimed to 95-standardize the fonnnulation for quality control purpose. Standard sample of the formulation was prepared in laboratory following the NFlJM methodology (National Formulary of Unani Medicine). Separate studies were undertaken for each ingredi ent in respect yl/um of pharmacognostical characters, physico-chemical constituents and HPTLC profile. Standard formulation was subjected to chemical anal ys is viz. extractive values, ash values, etc. including chromatographic profil e in li ne with standard pharmacopoe ial pctic protocols. The results may ensure the quality of f!abb-e-Mudir through determining the genuineness and quality of ingredients as well as the manufacturing process. pt iv e ~c ri a. cens.
Multi-herbs dominate as the largest segment, capturing a significant share of the overall herbal supplements and remedies market worldwide. The global herbal supplements and remedies market has been forecasted to reach about US$ 93.15 billion by the year 2015, spurred by increasing incidence of aging population and consumer awareness about general health and well being. Herbal product has been enjoying renaissance among the customers throughout the world. However, one of the impediments in the acceptance of these formulations is the lack of standard operating procedures (SOPs) for their development and quality control profile. Keeping the present demand of herbal products in view, in the present study, the poly herbal formulation Habb-e-Azaraqi which is commonly used in paralysis and arthritis has been developed by SOPs and various standardizing parameters has been evaluated, so as to ascertain its quality.
IJSRCH, 2023
The polyherbal drug Majoon-e-Maddat-ul-Hayat Jadwari has been used as a traditional and alternative medicine to treat and cure therapeutically in the treatment of Nisyan (Amnesia), Salasul Baul (Urinary Incontinence), Waja-ul-Kulya (Renal pain /Nephralgia), Waj-ul-Qutn (Lumbago), Waj-ul-Mafasil (Rheumatoid / Poly Arthritis) and has also been used Action wise Muqawwi-e-Asab, (Nervine Tonic), Muwallid-i-Mani (Spermatogenic), Hazim (Digestive), Daf-e-waja (Analgesic), Muqawwi-i-Bah (Aphrodisiac). In the present research study is aimed to evaluate the product drug standardization and quality validation using physico-chemical parameters; HPTLC fingerprinting, essential WHO and AYUSH Pharmacopeial parameters as per WHO and AYUSH guidelines protocols of analyzed parameters. Drug Standardization and product validation is very essential tools for validation and measured the batch to batch variation or uniformity of ASU herbal product. Therefore we need to develop standard validation techniques to standardize and validate of the poly herbal formulation. The drug MEMUHJ was prepared in three different batches as per the guidelines of Classical text / literatures of NFUM Vol, IVth Edition Ist and IInd. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain LOD/ Moisture ,w/w- (6.42%,6.69%,6.56%), Total ash, w/w- (1.66%,1.78%,1.66%), Acid in-soluble ash, w/w-(0.266%,0.323%,0.318%), Alcohol (ASEM) and Water (WSEM) soluble extractive matter, w/v- (53.66%,54.66%,55.04%) & (73.48%,74.01%, 74.41%) and Alcohol soluble successive extractive value (ASSEV). w/v- 54.92%,54.96%,54.90% , Chloroform soluble successive extractive value (CSSEV). w/v- 16.85%,16.72%,16.82%, pH (1% solution) (4.58,4.55, 4.51),pH(10% solution) (5.45,5.57, 5.75), Bulk density ,gm/ml - (1.525,1.515, 1.518),Reducing Sugar (54.31, 55.40, 54.80) and Non-Reducing Sugar(23.43,23.52,23.50) the HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The validation of quality control study revealed the absence of Microbial load, Aflatoxins, Heavy metal and Pesticide residues, The evaluated validated quality standards will be very useful for referential support, pharmaco-vigilance and validation of the standards of MEMUHJ providing the quality medicine to needful human being
International Journal of Scientific Research in Chemistry , 2023
Medicated Brain booster oil drug Raughan-e-Muqawwi-e-Dimagh a classical formulation used in the treatment of Brain Weakness, Insomnia, Amnesia and other Neurological disorders from since ancient time. Three drugs samples of REMED taken into these studies which 3 Batches were prepared B1,B2 and B3. and developed from applied SOP. on the basis of authenticated classical texts and literature of standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. The physicochemical data showed Extractive, %, w/v. (100), that the drug samples contained Petroleum ether(60-80°C), Acid value (69.12), Iodine value (23.99), Peroxide value(14.86), Saponification Value (248.29), Unsaponifiable matter,% (2.36),Refractive index (1.4657),Weight per ml.(gm.) (0.9006),Test for presence of Arachis oil, Cotton seed oil and Mineral oil both are found negatives and various bioactive phytochemical screening examined were assessed in REMED. HPTLC. studies of alcohol extracts of different Batches B1.B2 and B3 of REMED. Classical formulation showed various spots at 366nm (UV. region), under exposed to Vinyl - Sulfuric acid reagent. derivatized obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug samples. Moreover the obtained research studies data and comparative screening will provide the referential supportive information in the development of pharmacopeial standard monographs, identification of classical formulation, reinvestigation, quality assurance and pharmacovigilance and validation of the Quality standard of REMED classical drug providing the quality medicine to needful public mass of the World. KEYWORDS: Raughan-e-Muqawwi-e-Dimagh (REMED), Anti-amnesic,Medicated Brain booster oil, development of pharmacopeial standards, physicochemical, comparative screening, quality control and assurance.
Qualitative Estimation Of A Unani Poly-Herbal Formulation Habb-E-Yarqaan
IJCRT, 2023
Unani System of medicine is a traditional healing system with a rich history and the drugs used in this system are derived from natural sources. Majority of them i.e., about 85% from plant origin and the rest are from animal & mineral origin. To produce the desired therapeutic effect in Unani system of medicine, the quality and efficacy of the formulation is very crucial. Present study deals to evaluate quality & efficacy of a polyherbal Unani formulation Habb-e-Yarqaan widely used in the treatment of Jaundice. The present study was taken up to scientifically evaluate by the various physico-chemical parameters such as moisture content, loss on drying, extractive values such as water-soluble matter, ethanol soluble matter, percentage of ash values such as acid insoluble ash, water soluble ash and HPTLC analysis to identify various chemical components present in plant material. Evaluation of quality control parameters like heavy metal analysis, Microbial contamination, aflatoxin analysis and pesticide residue is also carried out in accordance with WHO guidelines such that the drug does not exceed the prescribed WHO limits for these parameter.
Iranian Journal of Aniaml Sciences
2015
This experiment was conducted to evaluate the effects using of different levels of rosemary hydro-alcoholic extract (Rosmarinus Officinalis L.) on productive performance and egg quality indicators, in laying hens. The levels of rosemary hydro-alcoholic extract in this experiment were 0, 500, 1000 and 1500ppm. This experiment was conducted in a Blok Completely Randomized Design with 160 “hy-line-W36” laying hens in 4 treatments and 4 replicate (with 10 hens in each replicate) from 29 until 38 weeks of age. The results showed that the using of different levels of rosemary hydro-alcoholic extract had significantly effects on some parameters of performance and egg traits in laying hens (P<0.05). Hence, the highest rate of egg production and egg mass (g/b/d) and the lowest feed conversion ratio were belong to birds fed diets containing 1000ppm rosemary hydro-alcoholic extract. Also the albumen quality (HU) of eggs maintained for 21 days at 4°C in the resulting eggs from the birds that...