Cytokine profiles during clinical high-flux dialysis : no evidence for cytokine generation by circulating monocytes (original) (raw)

Cytokine profiles during clinical high-flux dialysis were evaluated to investigate the potential generation of cytokines by circulating monocytes. In a crossover study involving patients undergoing different dialysis modalities, elevated levels of TNF-alpha, IL-1, and IL-6 were noted, particularly when compared with healthy controls. Despite these findings, there was no significant evidence to suggest that circulating monocytes contributed to the cytokine generation, as indicated by the analyses of dialysate cultures and endotoxin levels.