Efficacy of protease inhibitor-based anti-retroviral therapy in severe HIV-associated thrombocytopenia unresponsive to AZT (original) (raw)

1999, British Journal of Haematology

Abstract

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This study investigates the efficacy of protease inhibitor-based anti-retroviral therapy in patients with severe HIV-associated thrombocytopenia unresponsive to AZT. The analysis compares two groups receiving different treatments, revealing higher hospitalization and transfusion rates in the AZT group. Findings indicate that while both groups eventually achieved hematological remission, the timing and extent of recovery varied, with implications for treatment strategies in HIV-related hematological complications.

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References (12)

  1. Bazarbachi, A., Soriano, V., Pawson, R., Vallejo, A., Moudgil, T., Matutes, E., Peries, J., Molina, A., De The, H., Schulz, T.F., Catovsky, D. & Gill, P.S. (1997) Mycosis fungoides and Sezary syndrome are not associated with HTLV-I infection: an inter- national study. British Journal of Haematology, 98, 927-933.
  2. Boyd, M.T., Foley, B. & Brodsky, I. (1997) Evidence for copurification of HERV-K-related transcripts and a reverse transcriptase activity in human platelets from patients with essential thrombocythemia. Blood, 90, 4022-4030.
  3. Karlic, H., Mo ¨stl, M., Mucke, H., Pavlova, B., Pfeilsto ¨cker, M. & Heinz, R. (1997) Association of human T-cell leukemia virus and myelodysplastic syndrome in a central European population. Cancer Research, 57, 4718-4721.
  4. Karlic, H., Mo ¨stl, M., Pavlova, B., Nowotny, H., Pfeilsto ¨cker, M. & Heinz, R. (1998) Human T-cell leukaemia virus (HTLV-1)- positivity and myelodysplastic syndrome (MDS): association with subtypes, cytogenetics and del(5)(q)? British Journal of Haema- tology, 102, 169S.
  5. Loughran, T.P., Jr, Hadlock, K.G., Qing, Y., Perzova, R., Zambello, R., Semenzato, G., Foung, S.K.H. & Poiesz, B.J. (1997) Seroreactivity to an envelope protein of human T cell leukemia/lymphoma virus in patients with CD3 ¹ (NK) lymphoproliferative disease of granular lymphocytes. Blood, 90, 1977-1981.
  6. Xu, R., Gao, Q., Wang, S., Kan, H., Sheng, L., Li, C., Zhang, X., Xu, G. & Zhang, K. (1996) Human acute myeloid leukemias may be etiologically associated with new human retroviral infection. Leukemia Research, 20, 449-455.
  7. Clark, P., Brennand, J., Conkie, J.A., McCall, F., Greer, I.A. & Walker, I.D. (1998) Activated protein C sensitivity, protein C, protein S, and coagulation in normal pregnancy. Thrombosis and Haemostasis, 79, 1166-1170.
  8. Cumming, A.M., Tait, R.C., Fildes, S., Yoong, A., Keeney, S. & Hay, C.R. (1998) Development of resistance to activated protein C during pregnancy. British Journal of Haematology, 90, 725-727.
  9. Mathonnet, F., de Masancourt, P., Denninger, M.-H., Marot, M., Benattar, N. & Giudicelli, Y. (1996) Role of factor VIII on activated protein C resistance ratio on inflammatory diseases. British Journal of Haematology, 95, 423-425.
  10. Olivieri, O., Manzato, F., Guella, A., Bernardi, F., Lunghi, B., Gizelli, D., Azzini, M., Brocco, G., Russi, C. & Corrocher, R. (1995) Resistance to activated protein C in healthy women taking oral contraceptives. British Journal of Haematology, 91, 465-470.
  11. Ripoll, L., Mazoyer, E., Baudin, B., Lacam, S., Varsat, B. & Drouet, L.O. (1998) Can high plasma caeruloplasmin levels cause acquired activated protein C resistance? Thrombosis and Haemo- stasis, 79, 449-450.
  12. Walker, F.J. & Fay, P.J. (1990) Characterisation of an interaction between protein C and caeruloplasmin. Journal of Biological Chemistry, 265, 1834-1836.