SpeculationAttachment of the antigen receptor to the B cel membrane (original) (raw)

Models for the attachment of antigen receptors to the B cell membrane and some of the issues which arise on a consideration of this problem are discussed with reference to IgM receptors. It is suggested that the binding to the membrane may be a consequence of a unique structural feature of receptor immunoglobulin. Alternatively this may be a result of the subcellular site of biosynthesis of the receptor or the presence of a specific proreceptor molecule. Experiments to differentiate between the models are briefly discussed.