Herbal medicines and chronic kidney disease (original) (raw)
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Néphrologie & Thérapeutique, 2019
Background Traditional medicine, which includes plants, has been increasingly used worldwide, especially in people with chronic conditions [1-4]. The prevalence of herbal medicine use in the previous 12 months of 2008 was 33.9% in Malaysia [3], 18.9% of the US adult population reported using natural herbs in past 12 months of 2002 [4], 10% in Australia used at least once herbal medicines in 1993 [5]. Patients with kidney disease have shown a higher prevalence of herbal medicine usage [3,7]. According to a study in northern Tanzania between December 2013 and June 2014, the prevalence of traditional medicine use in patients with chronic kidney disease (CKD) was 70.3% [8]. This use may be a risk factor of this pathology, knowing that about 35% of acute kidney injury cases are caused by traditional remedies in the developing world [9,10]. Additionally, it has been documented in many recent studies that several herbal medicine induce adverse renal effects ranging from worsening kidney function to renal failure [11-13].
Kidney disease has always under concerned area since a long time specially in developing and under developing countries. It is one of the leading cause of death in world today. Incidence of kidney diseases leading to kidney failure is increasing day by day. The use of herbal drugs for the prevention and treatment of various diseases is now considered in thought throughout the world. A number of extracts of natural products have been reported to show protective effects against nephrotoxicity. Many herbal drugs have shown their potent nephroprotective effect due their antioxidant, diuretic, anti-inflammatory, antispasmodic properties. WHO has recently reported that traditional medicines have been existing in therapeutic practice even hundred years before the development of modern medicine. As herbs and herbal drugs have clinically proven effects like immunomodulation, adaptogenic and antimutagenic, they play a vital role in treatment of kidney diseases progressive to failure. Number of medicinal plants shows activity such as Punarnava &Varun reduces elevated blood urea & Serum Creatinine, Shigru & Sariva increase functional capacity like prevent renal injuries, helps improve haemopoiesis, Kasni restores electrolytic homeostasis like sodium and Pottasium, Revand Chini detoxify the effect like significantly reduces the deposition of 2,8-dihydroxyadenine content, Shigru acting as anti oxident, Shirish, Amalaki, Haritaki, Punarnava act as immunomodulator, Papaya, Coriandar reducing renal hypertention, Makoi, Purnarnava reduces oxidative stress. There are various evidences which revalidate the folklore use of traditional medicines and even be helpful in the development of future medicines, treatments and treatment guidelines of kidney disease.
American Journal of Kidney Diseases, 2004
The use of herbal therapy has increased dramatically in past years and may lead to renal injury or various toxic insults, especially in renal patients. In most countries, herbal products are not regulated as medicines. Herbal poisoning may be secondary to the presence of undisclosed drugs or heavy metals, interaction with the pharmacokinetic profile of concomitantly administered drugs, or association with a misidentified herbal species. Various renal syndromes were reported after the use of medicinal plants, including tubular necrosis, acute interstitial nephritis, Fanconi's syndrome, hypokalemia or hyperkalemia, hypertension, papillary necrosis, chronic interstitial nephritis, nephrolithiasis, urinary retention, and cancer of the urinary tract. It seems critical that caregivers be aware of the potential risk of such often underreported therapy and carefully question their patients about their use of this popular branch of alternative medicine. Am J Kidney Dis 44:1-11.
Journal of Laboratory and Clinical Medicine, 2006
Chronic kidney disease (CKD) is an increasingly common condition with limited treatment options that is placing a major financial and emotional burden on the community. The use of complementary and alternative medicines (CAMS) has increased many-fold over the past decade. Although several compelling studies show renal toxicities and an adverse outcome from use of some CAMS, there is also emerging evidence in the literature that some may be renoprotective. Many nephrologists are unaware of these potential therapeutic benefits in treating CKD, or they are reluctant to consider them in research trials for fear of adverse effects (including nephrotoxicity) or deleterious interaction with co-prescribed, conventional medicines. The increased use of self-prescribed CAMS by their patients suggests that practitioners and researchers should keep abreast of the current information on these agents. A primary goal of this article was to review the available scientific evidence for the use of herbs or natural substances as a complementary treatment for patients with CKD. A further goal was to report the literature on herbs that have been reported to cause kidney failure. (J Lab Clin Med 2006;147:160-166) Abbreviations: AA ϭ aristolochic acid; A&A ϭ Astragalus and Angelica; AAN ϭ aristolochic acid nephropathy; ACE ϭ angiotensin-converting enzyme; BUN ϭ blood urea nitrogen; CAMS ϭ complementary and alternative medicines; CKD ϭ chronic kidney disease; Cs ϭ Cordyceps sinesis; LSB ϭ lithospermic acid B; MMF ϭ mycophenolate mofetil; NAG ϭ N-acetylglucosaminidase; Scr ϭ serum creatinine; ST ϭ Sairei-to
Traditional herbal remedies used in kidney diseases in Turkey: an overview
TURKISH JOURNAL OF BOTANY, 2021
Introduction Kidney diseases are a significant public health problem which can lead to end-stage kidney failure and serious complications. The increasing prevalence of chronic kidney disease that causes high morbidity and mortality has reached to alarming levels all over the world. It is estimated that nowadays more than 1.4 million patients undergoing renal replacement therapy worldwide (Kazancıoğlu, 2013; Bikbov et al., 2020). According to the latest reports chronic kidney disease affects approximately 15.7% of population in Turkey (Ateş, 2020). Since there are some preventable risk factors leading to kidney diseases, identification of them is essential to maintain individual health and inhibition of progression of the disease. Kidney diseases associated with smoking, obesity, hypertension, and diabetes mellitus have been well documented. Moreover, factors such as race, gender, age, and family history have also been considered (Kazancıoğlu, 2013; Ateş, 2020). Despite the advancement in medical science, there are few treatment methods to cure kidney diseases. Patients have looked for more affordable, accessible and reliable options, therefore, the use of herbal remedies or natural products has gained much attention (Touwaide et al., 2005; Karimi et al., 2017). Medicinal plants have been serving mankind in treating diseases and improving health since ancient times. In recent years, scientific researches have proven that bioactive compounds from medicinal plants offer a good and safer alternative to modern synthetic drugs (Cotton, 1996; Baytop, 1999; Kendir and Güvenç, 2010; Yeşilada, 2013). The uses of traditional herbal remedies for the treatment of kidney diseases are common in many countries. Several medicinal plants such as Vaccinium macrocarpon Aiton, Harpagophytum procumbens DC. ex Meissner, Schisandra chinensis (Turcz.) Baill., Filipendula ulmaria (L.) Maxim, Tinospora cordifolia (Willd.) Miers, Astragalus sp. and Rheum sp. have been used by local people for various kidney problems, especially in Europe and Asia (Heinrich et al., 2012; Singh and Sharma, 2013; Zhong et al., 2013). In many countries, benefit from natural resources for medicinal use and other purposes are closely linked with the floristic richness and the accumulation of Abstract:Ethnobotanical and ethnomedicinal studies have become increasingly recognised as a valuable source of information on the use and possible pharmacological activity of many plant species. There is no study presenting traditional herbal remedies used for kidney diseases in Turkey. The purpose of the paper is to compile herbal remedies used in kidney diseases in Turkey with detailed usage information and chemical constituents. The botanical names, families, and local names; used parts; preparation methods; administration/ dosage; kidney problems and chemical constituents were presented by screening ethnobotanical, ethnomedicinaland phytochemical studies. The most cited plant families, the most cited genera, and the most frequently used plant parts were determined and presented in graphics. In total, 300 taxa belonging to 70 families were determined as being traditional herbal remedies used in kidney diseases. Asteraceae (57), Lamiaceae (33), Rosaceae (30), Fabaceae (16), Malvaceae (15), Apiaceae (13) and Poaceae (10) were found as the most cited plant families. The most cited genera were Helichrysum (44), Equisetum (27), Tribulus (23), Urtica (23), Rosa (17), Alcea (14), Hypericum (14) and Paliurus (14), respectively. It was found that the aerial parts were the most frequently used part of theplant, accounting for 28%. Following in this category are leaves (19%), flowers (14%), fruits (14%), underground parts (13%), seeds (5%), stem (3%), and other parts (4%). The pharmacological studies of the most cited genera were also reviewed to confirm the efficacy of these plants inthe treatment of kidney diseases. It is concluded that a number of pharmacological and phytochemical research support the traditional usage of plants, but further studies are needed. Our findings are expected to be the basis for candidate pharmaceutical products.
Journal of Renal Endocrinology
Each year, a considerable number of individuals are diagnosed with potentially life-threatening renal failure, encompassing acute kidney injury (AKI) and chronic kidney disease (CKD). New natural herbal compounds, whether used in isolation or combined with medical treatments and an appropriate regime, have been suggested for the management of renal failure. The etiology of AKI remains uncertain; nevertheless, several factors have been proposed as potential causative agents that can lead to renal failure, including renal ischemia-reperfusion injury (IRI), nephrotoxicity, sepsis, administration of radiocontrast agents, and exposure to heavy metal ions. Several commonly utilized herbs with anti-diabetic and antihypertensive properties, known for their antioxidant, anti-inflammatory, and vasorelaxant effects, have been recognized as efficacious therapeutic agents in the management of CKD. The management of renal failure typically involves treating the underlying diseases, such as IRI, s...
Egyptian Journal of Veterinary Sciences, 2022
K IDNEY failure (CKD) is a debilitating disease that results in severe renal failure. The kidneys are destroyed very slowly and fail. Weakness, lethargy, chronic fatigue, paleness, swelling of the hands and feet, or puffiness around the eyes and high blood pressure are some of the symptoms of kidney failure. The aim of this study was to herbs used in Iranian ethnopharmacological knowledge in order to identify medicinal plants affecting renal failure. In this review study, keywords such as renal failure, renal impairment, hypertension, diabetes, herbs, ethnobotany, ethno-veterinary, ethnopharmacology, and Iran were used. Databases such as ISI, WOS, Scopus, IslamicWorld Science Citation Center, Scientific Index database and Google Scholar were used to review articles and resources. Finally, 23 articles containing ethno-pharmacological information for the treatment of renal failure were used to review the literature. Medicinal plants such as L. album
International Journal of Botany Studies, 2021
Disputes in kidney disease (KD) incidence and progression are commonly believed to be based upon group differences in the prevalence of risk factors for KDs, such as diabetes, hypertension, and obesity. But the prevalence of these comorbidity disorders does not fully explain the increased rate of developments in high-risk populations from chronic kidney disease (CKD). Renal diseases arise as renal function losses eventually resulting in total kidney failure. There is no complete understanding of the processes underlying the causes and development of KDs. The kidneys are a common target organ for the toxicity of different environmental compounds and agents from contact. We must recognize both chemical and pathological pathways and factors that could alter the susceptibility of injury to understand the risk to human health from exposures like these. At present, the test for early disease, predicting disease progression or monitoring therapeutic response is not sufficiently sensitive or specified. Despite several advances in treatment and understanding acute renal failure (ARF) pathogenesis, there persist conflict, ambiguity, and lack of certainty on many aspects in that field. The incidence, etiology, and clinical characteristics of RF are important in promoting preventative strategies and the use of sufficient resources for managing the disease. The article contains brief information about kidney failure, different KDs, their risk factor, prevention and also contains numerous herbs that are effective in the treatment of KDs.
Kidney disorders and management through herbs: A Review
The Journal of Phytopharmacology
Kidneys have a vital role in the normal physiology of humans. Worldwide chronic kidney disease has become a major cause for disability and in worst circumstances leads to death. Major renal disorders occur due to diabetes and its complications termed as diabetic nephropathy (DN). Also nephrolithiasis occurs due to presence of organic debris of carbohydrates, lipids and proteins and supersaturation with calcium oxalate in the renal system. The article comprises of various herbs proven to be used in management of these disorders