Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli (original) (raw)

MGG Molecular & General Genetics, 1972

Abstract

In the course of experiments directed towards the isolation of mutants of Escherichia coli K12 with altered regulation of the synthesis of carbamoylphosphate synthetase, two types of mutations were found to affect the cumulative repression of this enzyme by arginine and uracil. Alteraction of the arginine pathway regulatory gene, argR, was shown to reduce the repressibility of the enzyme by both end products while mutations affecting uridine monophosphate pyrophosphorylase (upp) besides affecting uracil uptake preclude enzyme repression by uracil or cytosine in the biosynthesis of carbamoylphosphate and the pyrimidines. The upp mutations were located on the chromosome near the gua operon. Mutations previously designated as uraP are shown to belong to this class.

Andre Pierard hasn't uploaded this paper.

Let Andre know you want this paper to be uploaded.

Ask for this paper to be uploaded.