Knee Cartilage T2 Characteristics and Evolution in Relation to Morphologic Abnormalities Detected at 3-T MR Imaging: A Longitudinal Study of the Normal Control Cohort from the Osteoarthritis Initiative (original) (raw)
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T2* measurement of the knee articular cartilage in osteoarthritis at 3T
Journal of Magnetic Resonance Imaging, 2012
Purpose: To measure reproducibility, longitudinal and cross-sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects with osteoarthritis (OA) and healthy matched controls. Materials and Methods: MRI data and standing radiographs were acquired from 33 subjects with OA and 21 healthy controls matched for age and gender. Reproducibility was determined by two sessions in the same day, while longitudinal and cross-sectional group differences used visits at baseline, 3 and 6 months. Each visit ...
Journal of Magnetic Resonance Imaging, 2013
Purpose-To study the natural evolution of cartilage T 2 relaxation times in knees with various extents of morphological cartilage abnormalities, assessed with 3T MRI from the Osteoarthritis Initiative. Materials and Methods-Right knee MRIs of 245, 45-60 year old individuals without radiographic OA were included. Cartilage was segmented and T 2 maps were generated in five compartments (patella, medial and lateral femoral condyle, medial and lateral tibia) at baseline and two-year follow-up. We examined the association of T 2 values and two-year change of T 2 values with various Whole-Organ MR Imaging Scores (WORMS). Statistical analysis was performed with ANOVA and Students t-tests. Results-Higher baseline T 2 was associated with more severe cartilage defects at baseline and subsequent cartilage loss (P<0.001). However, longitudinal T 2 change was inversely associated with both baseline (P=0.038) and follow-up (P=0.002) severity of cartilage defects. Knees that developed new cartilage defects had smaller increases in T 2 than subjects without defects (P=0.045). Individuals with higher baseline T 2 showed smaller T 2 increases over time (P<0.001).
High resolution T2* mapping in assessment of knee articular cartilage on 3T MRI
Journal of Clinical Orthopaedics and Trauma, 2022
Objective: To evaluate the spectrum of T2* values in healthy cartilage of young asymptomatic adults on high resolution 3T MRI. Methods: A total of 50 asymptomatic adult volunteers with age ranging from 18 to 35 years were enrolled for the study with the purpose of assessing T2* values in healthy cartilage without any degenerative changes. The articular cartilage was assessed on two sections, one each through the medial and lateral compartments. The cartilage was segmented into 8 regions through the tibio-femoral and patella-femoral joints. Further post processing was done using multiple ROI placement to delineate ROI areas for calculation of full thickness and zonal (superficial and deep) T2* values. Thus, a total of 1200 ROI areas (50 volunteers, 8 segments, and 3 areas for each segment) were assessed. Results: The results revealed a superior bulk T2* value of 29.2 ± 3.6 ms from the posterior medial femoral cartilage and 26.1 ± 3.1 ms from the patellar region. Intermediate values were obtained from posterior lateral femoral cartilage, central femoral cartilage, and trochlea. The tibial plateau cartilage had the lowest values e 19.6 ± 2.6 ms for the medial tibial plateau and 20.6 ± 2.8 ms for lateral tibial plateau. The study demonstrated substantial regional physiological variation existing in the T2* values across various regions of the knee joint, which could be attributed to varying amounts of shearing forces across the joint. No significant differences were noted in bulk T2* values between the two genders, with only the trochlear segment revealing significantly increased values in males (p ¼ 0.007). All the cartilage segments revealed significantly increased T2* values in the superficial zone as compared to the deep zone. Conclusion: There is a significant regional difference in the bulk T2* values of articular cartilage in a normal physiological state across various joint segments. A zonal gradient with increasing values from the deep to the superficial zone also exists. These findings can prove invaluable in assessing changes in T2* values occurring in diseased/degenerative cartilage.
European review for medical and pharmacological sciences, 2014
OBJECTIVE To identify changes in knee joint cartilage transverse relaxation values depending on the patient's age and gender and to investigate the relationship between knee joint pathologies and the transverse relaxation time. PATIENTS AND METHODS Knee MRI images of 107 symptomatic patients with various pathologic knee conditions were analyzed retrospectively. T2 values were measured at patellar cartilage, posteromedial and posterolateral femoral cartilage adjacent to the central horn of posterior meniscus. 963 measurements were done for 107 knees MRI. Relationship of T2 values with seven features including subarticular bone marrow edema, subarticular cysts, marginal osteophytes, anterior-posterior cruciate and collateral ligament tears, posterior medial and posterior lateral meniscal tears, synovial thickening and effusion were analyzed. T2 values in all three compartments were evaluated according to age and gender. RESULTS A T2 value increase correlated with age was present i...
Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis
Osteoarthritis and Cartilage, 2007
Objective: The transverse relaxation time constant, T 2 , of articular cartilage has been proposed as a biomarker for osteoarthritis (OA). Previous studies have not clearly defined the relationship between cartilage T 2 values and clinical methods of grading OA or known factors associated with OA. This study compared T 2 values of patellar cartilage grouped by radiographic stage of patello-femoral OA and by body mass index (BMI). Methods: T 2 values of patellar cartilage were calculated for 113 subjects using images acquired on a 1.5 T clinical scanner. Radiographs of the patello-femoral joint were graded for OA grading using the KellgreneLawrence scale. Results: No differences of T 2 values were found across the stages of OA (P ¼ 0.25), but the factor of BMI did have a significant effect (P < 0.0001) on T 2 value. Conclusions: The results indicate the T 2 values are not sensitive to changes in radiographic stages of OA. In addition, differences of T 2 values with BMI signify structural changes occurring within the patello-femoral joint and that BMI may be considered a factor for a potential increase of T 2 values. Future studies comparing different OA grading methods with T 2 mapping may highlight the sensitivity of T 2 mapping in a clinical setting.