The effect of portal blood bile salt concentrations on bile salt synthesis in rat liver (original) (raw)
This study investigates the synthesis of conjugated bile salts in rat hepatocytes and its modulation by portal blood bile salt concentrations, specifically under diurnal light conditions. Notably, the research confirms that bile salt synthesis exhibits a diurnal rhythm, being significantly higher during the dark phase. Additionally, feeding cholestyramine increases bile salt synthesis despite decreased portal concentrations of specific bile salts, suggesting that feedback inhibition in bile salt synthesis does not occur directly at the concentrations found in vivo.