Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists (original ) (raw )New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors α/γ Dual Agonists with Improved Potency and Reduced Adverse Effects on …
Antonio Lavecchia
Journal of medicinal …, 2009
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Design and Synthesis of N -[(4-Methoxyphenoxy)carbonyl]- N -[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities
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Journal of Medicinal Chemistry, 2005
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Journal of Medicinal Chemistry, 2009
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Timothy Phillips
Journal of Biological Chemistry, 2004
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Journal of Medicinal Chemistry, 2002
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[4-(2H-1,2,3-Benzotriazol-2-yl)phenoxy]alkanoic Acids as Agonists of Peroxisome Proliferator-Activated Receptors (PPARs)
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New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression
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Molecular Endocrinology, 2005
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Metabolism-clinical and Experimental, 2008
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In-silico Analysis of Phenyl Propanoic Acid Derivatives to Design Potent Peroxisome Proliferator-activated Receptor (PPAR) Dual Agonists for Type 2 Diabetes mellitus Therapy
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Bioorganic & Medicinal Chemistry, 2012
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Walter Wahli
Molecular Endocrinology, 2002
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Medicinal Chemistry Research, 2014
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Bioorganic & Medicinal Chemistry Letters, 2007
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P633H, a novel dual agonist at peroxisome proliferator-activated receptors α and γ, with different anti-diabetic effects in db/db and KK-A y mice
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British Journal of Pharmacology, 2009
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Peroxisome Proliferator-Activated Receptors as Superior Targets for Treating Diabetic Disease, Design Strategies - Review Article
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Bioorganic & Medicinal Chemistry, 2011
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PAR-5359, a well-balanced PPARα/γ dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo
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European Journal of Pharmacology, 2008
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Peroxisome proliferator-activated receptors: Targets for the treatment of metabolic illnesses (Review)
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Biochemical Pharmacology, 2014
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The American Journal of Cardiology, 2007
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Bioorganic & Medicinal Chemistry Letters, 2010
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European Journal of Medicinal Chemistry, 2012
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Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents
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Bioorganic & Medicinal Chemistry Letters, 2011
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