Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine (original) (raw)

Kidney International, 2009

Abstract

Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme had a reduced activity. Here we measured the effect of an infusion

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