Tauopathic Changes in the Striatum of A53T alpha-Synuclein Mutant Mouse Model of Parkinson's Disease (original) (raw)

Plos One, 2011

Abstract

Tauopathic pathways lead to degenerative changes in Alzheimer's disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson's disease [PD]. We have examined tauopathic changes in striatum of the α-synuclein (α-Syn) A53T mutant mouse. Elevated levels of α-Syn were observed in striatum of the adult A53T α-Syn mice. This was accompanied by increases in

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