SYNTHESIS, CHARACTERISATION AND BIOLOGICAL STUDIES OF METAL COMPLEXES OF THE SCHIFF BASE {2-[FURAN-2-YL METHYLENEAMINO]PYRIDINE-3-OL (original) (raw)
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Dutse Journal of Pure and Applied Sciences (DUJOPAS), 2020
Complexes of Mn(II)and Fe(II) with Schiff based derived fromsulfamethoxazole andfurfural have been prepared and characterized on the basis of physical characteristics, analytical data, FTIR spectral studies and elemental analysis. Infrared spectra of the Schiff base and the complexes agrees with the formation and chelation of the Schiff base through the azomethine nitrogen at 1629 cm-1 and aldehydic oxygen at 1288 cm-1. Molar conductance measurement of 5.29 and 9.68 Ohm-1 cm 2 mol-1 suggesteda nonelectrolytic nature of the complexes. Magnetic susceptibility data (5.84 and 5.12 BM)suggested octahedral structure for all the complexes. Elemental analysis suggested the ligand-metal ratio of2:1 respectively. The Schiff base melted at 180°C and the complexes decomposedat 232°C and 227°C implying thermal stability. The Schiff base and the complexes have been screened for their antimicrobial activity against four pathogenic microbes;Staphylococcus aureus, Escherichia coli, Aspergillus flavusand Candida albicans. The ligand showed moderate activity with inhibition zone in the range of 6-14mm, while the metal complexes exhibited higher antimicrobial activity with inhibition zone of 9-18mm against the tested microbes.
2021
Schiff base formed by condensation of 3-formylchromone and benzohyrazide and its metal(II) complexes of Mn(II), Fe(II), and Co(II), have been prepared and characterized by conductivity measurement, magnetic susceptibility, IR Spectra, atomic absorption spectroscopy, elemental analysis, as well as melting point/decomposition temperature and solubility test. The melting point of the Schiff base (165 0 C) and decomposition temperatures of the complexes (185-198) 0 C indicating their thermal stability. The molar conductivity measurement determined are in the range (10.54-23.10) Ω-1 cm 2 mol-1 revealing that all the complexes are non-electrolytic in nature. IR spectra of the Schiff base showed a band at 1633cm-1 which assigned to ʋ(-C=N-) stretching vibration. This band was observed downfield in the range (1603-1655) cm-1 in the spectra of the metal(II) complexes revealing that the Schiff base formed metal complexes with the metal ions. The gram magnetic susceptibility measurements of the complexes showed that all the complexes except that of Zinc are paramagnetic and have tetrahedral geometry. The elemental analysis suggested a metal to ligand ratio of 1:1. The Schiff base and its metal complexes have been screened for their antimicrobial activity against four pathogens. Some compounds were active, while others are not active against the isolates
A new transition metal complexes of Mn(II) and Fe(III) were prepared from bidentate Schiff base. The Schiff base ligand synthesized from the condensation of P-chlorobenzaldehyde and 2-amino-4-hydroxy-6-methylpyrimidine (L5) in alcohol medium. These metal complexes were characterized on the basis of their micro analytical data, molar conductance, magnetic susceptibility, IR, UV-Vis, 1H NMR, X-ray diffraction, thermogravimetric analysis. The ligand and their metal complexes were screened for fungicidal activity against various fungi like Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergllus flavus. The antibacterial activity against various bacteria like Escherichia coli, Salmonellatyphi, Staphylococcus aureus, B.subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities. Keywords: Schiff bases, Transition metal complexes, Thermal analysis, Powder X-ray diffraction, Antimicrobial activity.
The aim of the present work is to synthesize some Schiff base complexes of metal ion and to evaluate their antimicrobial activities. Novel Schiff base ligand derived from 2-hydroxybenzophenone with S-benzyldithiocarbazate and its metal complexes with Ni (II), Cu (II), Zn (II) and Cd (II) have been synthesized and evaluated for their antibacterial activities by disc diffusion method and antifungal activities by PDA medium. The complexes have been characterized by conductance, magnetic, IR and electronic spectroscopic techniques.
FUDMA JOURNAL OF SCIENCES, 2020
Schiff base derived from 2-aminophenol and 2-hydroxy-6-methoxy-3-quinolinecarboxaldehyde and its Co(II) and Ni(II) complexes were synthesized and characterized by elemental analysis, melting point and decomposition temperature, molar conductivity, IR spectral analysis, AAS analysis, solubility test, and magnetic susceptibility. The FTIR spectral data of the Schiff base determined showed a band at 1622cm-1 which was assigned to the v(C=N), a feature of azomethine group. The same band was observed to shift to lower frequencies 1577 and 1599cm-1 in the complexes suggesting coordination of the Schiff base with the respective metal (II) ions. Molar conductance values 14.58 and 12.65Ω-1cm2mol-1show that the metal complexes were non-electrolytic in nature. The magnetic susceptibility of the complexes were determined and the gram magnetic susceptibility of the complexes were found to be positive, revealing that they are paramagnetic. The elemental analysis of the complexes for C, N and H d...
Metal complexes of Mn(II), Fe(II), Co(II) and Cd(II) ions with Schiff base ligand 4-{(pyridin-2-ylimino)methyl}phenol derived from condensation of 2-amino pyridine with 4hydroxybenzaldehyde was prepared. The ligand and complexes were isolated from the reaction in the solid form and characterized by conductivity, magnetic moment, TLC, IR, UV-Visible, thermal analysis and some physical measurements. During complexation reaction with transition metal ions Schiff base act as a deprotonated tridentate ligand and IR spectra showed that N and O atoms are coordinated to the central metal atom. The observed values confirmed that the complexes have octahedral geometry. The Schiff base and its metal complexes have been found to have moderate to strong antibacterial activity.
World Journal of Innovative Research, 2020
Fe(II), Mn(II), Zn(II), Co(II) and Cu(II) complexes of Schiff base were synthesized and characterized by different physico-chemical techniques. The metal (II) complexes were characterized by solubility testing, melting point, molar conductance, UV-Vis and FTIR spectral studies. The high melting point of the complexes showed stability of the metal complexes. The values of molar conductance of the Schiff base, and all the metal (II) complexes are in the range of 3.0-36.6 S.cm2 mol-1. These values indicate that they are all non-electrolytes. The UV-Vis spectral studies have shown hypochromic shift in the metal (II) complexes of the Schiff base. The FT-IR spectral have shown that the Fe(II), Mn(II), Zn(II), Co(II) and Cu(II) ions coordinated to the Schiff base through the v(C=N) at 1618 cm-1. The v(OH) of the Schiff base at 3469 cm-1 disappeared in the metal(II) complexes showing the deprotonation and binding of the hydroxyl oxygen to the metal atom. The ability of these metal(II) complexes to inhibit the growth of disease causing organisms such as Staphylococcus aureus (Gram positive bacteria), E.coli, Klesiella pneumonia, Salmonella typhi (Gram negative bacteria) and Aspergillus niger and Candida albicans (Fungi isolates) were compared with the standard drugs (erythromycin and fungusol) respectively. The results of antimicrobial activity have revealed that most of the complexes are more potent against the isolated microbes as compared to the standard drugs.
The Pharma Innovation Journal, 2016
The new bidentate Schiff base ligand namely [(E)-N 1-(4-methoxy benzylidene) benzene-1, 2-diamine] was prepared from condensation of 4-Methoxy benzaldehyde with O-Phenylene diamine at 1:1 molar ratio in ethanol as a solvent in presence of drops of 48% HBr. The structure of ligand (L) was characterized by, FT-IR, U.V-Vis., 1 H-, 13 C-NMR spectrophotometer, melting point and elemental microanalysis C.H.N. Metal complexes of the ligand (L) in general molecular formula [M(L)3], where M= Mn(II), Co(II), Ni(II),Cu(II) and Hg(II); L=(C14H14N2O) in ratio (1:3)(Metal:Ligand) were synthesized and characterized by Atomic absorption, FT-IR, U.V-Vis. spectra, molar conductivity, chloride content, melting point and magnetic susceptibility from the above data the geometrical formula was octahedral for all complexes. And in vitro tests for antibacterial activity showed that most of the prepared compounds display activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeruginosa).
A novel Schiff-base ligand and its Ni(II) & Cu(II) complexes were synthesized and well characterized by elemental analyses and spectral studies. Physical and analytical data suggest that the Schiff base acts as tridentate ligand towards metal ions via azomethine-N, deprotonated-O of 2-aminophenol and O-atom of furan moiety. The synthesized ligand, along with its metal complexes were screened for their in-vitro antibacterial activity against four bacterial pathogens (E. coli, Bacillus subtilis, Staphylococcus aureus and P. vulgareous ). The results of these studies revealed that the free ligand and its metal complexes showed significant antibacterial potency.
Journal of advanced scientific research, 2022
Novel classes of heterocyclic Schiff base ligand were prepared from the condensation of 2-methoxy benzaldehyde and 2amino 4-methyl pyridine in absolute ethanol in presence of catalytic amount of dilute HCl. The resulted novel class of heterocyclic ligand was treated with metal salt or acetate results in the formation of Fe (III), Co (III), Ni (II) & Cu (II) complexes. All newly synthesized resulted ligand its metal complexes were characterized by elemental analysis and FT-IR, Magnetic susceptibility, Antimicrobial, Antioxidant, ESR spectrum for Copper complex in DMF solvent recorded at room temperature. The Electronic spectra and magnetic susceptibility measurements indicates that square planer and octahedral geometry of these complexes also suggest their structure in which (N, O) group acts as bidentate ligand. The thermal stability, decomposition behavior has been investigated by using thermo gravimetric analysis at heating rate 10°C per minute with nitrogen atmosphere and their and kinetic parameter was also calculated by using Freeman Carroll method. Screening results of antimicrobial, antioxidant activity of transition metal complexes shows good antibacterial and antifungal activity and excellent antioxidant activity.