Lipid rafts and host cell-pathogen interactions (original) (raw)
tool to isolate raft-containing domains from cells. These domains have been differently called DRM, DIGS, GEMS, TIFF and can associate with specific proteins while excluding others. Proteins with raft affinity are glycosylphosphatidylinositol (GPI)-anchored proteins, 7 doubly acylated proteins such as the α-subunits of heterotrimeric G proteins and Src-family kinases, cholesterol-linked and palmitoylated proteins, and transmembrane proteins, in particular the ones carrying palmitoylation motifs (for review see ref. 6). These proteins can transiently associate with rafts, which modulate their function.
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