An Activation-Induced Cytidine Deaminase-Independent Mechanism of Secondary VH Gene Rearrangement in Preimmune Human B Cells (original) (raw)
2008, The Journal of Immunology
AI-generated Abstract
This study investigates a novel mechanism of VH gene rearrangement in preimmune human B cells that operates independently of activation-induced cytidine deaminase (AID). It demonstrates that cryptic recombination signal sequences (cRSS) within VH gene segments can facilitate secondary recombinations, thus enabling changes in B cell receptor specificity even in the absence of AID. Results indicate that this mechanism is significant for the generation of a diverse Ig repertoire and has implications for understanding B cell development and autoimmune responses.
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