Receptor-Signaling Pathways in Heart Failure (original) (raw)

Principles of Molecular Cardiology, 2005

Abstract

Heart failure, a progressive disorder characterized by deterioration of cardiac function and premature myocardial cell death, results from several common heart diseases such as coronary atherosclerosis, hypertension, and valvular diseases (1,2). With almost 550,000 new cases diagnosed each year, heart failure affects an estimated 4.7 million Americans, and costs associated with the disease range from 10 billion to10 billion to 40 billion per year (3). The aggregate 5-year mortality of patients with heart failure is about 50%, while the 1-year mortality of patients with advanced disease may exceed 50% (3). To maintain adequate myocardial contractility in response to injury, the heart uses several mechanisms, including hypertrophy of myocardial cells, changing the energetics of myocardial cell contraction, and upregulating transcription of several genes (4,5).

Liza Barki-harrington hasn't uploaded this paper.

Let Liza know you want this paper to be uploaded.

Ask for this paper to be uploaded.