Bioavailability, biodistribution, and toxicity of biozn-aas 1 1 BioZn-AAS has been assigned patent number 9800574. : a new zinc source. comparative studies in rats (original) (raw)

Food fortification with a proper zinc compound is an economic and effective strategy to prevent zinc deficiency. BioZn-AAS, a zinc gluconate stabilized with glycine, was compared with zinc sulfate (reference standard), zinc hydroxide, and zinc gluconate, all of them labeled with 65 Zn. This preclinical study was performed on Sprague-Dawley rats of both sexes, and the administered dose was 85 g/kg of zinc. Bioavailability studies showed that absorption of BioZn-AAS was not statistically different than absorption from other sources in female rats 25.65% Ϯ 2.20% for BioZn-AAS, 28.24% Ϯ 4.60% for ZnSO 4 , 24.91% Ϯ 4.02% for Zn[OH] 2 , and 25.51% Ϯ 2.70% for Zn-gluconate). In the case of the male rats, absorption of BioZn-AAS (27.97% Ϯ 4.20%) was higher (PϽ0.05) than that from the other compounds (23.15% Ϯ 2.90% for ZnSO 4 , 22.62% Ϯ 3.90% for Zn[OH] 2 , and 22.30% Ϯ 3.90% for Zn-gluconate)