A NEW SYNTHESIS OF LH-1,3-OXAZINES (original) (raw)

New Approach for the Synthesis of Aryloxy 1,3-OXAZINES

International Journal of Research -GRANTHAALAYAH, 2020

Oxazine compounds have drew the attention of many researchers to find different approaches to the synthesis of this type of compounds according to the success of their use in a wide range of pharmaceutical application during the last decades .It is also for the difference reactivity of these analogues is exhaustively depicted and illustrates the rich versatility of this class of starting material. They proved to have most of actions of a combination of other drugs. We are herein investigate the synthesis of ethyl aryloxy acetate(S1-6) from the reaction of the corresponding ethyl bromo acetate with aryl phenols .These intermediates were cyclized with antharanilic acid affording the titled compounds

Synthesis of 1-alkyl(aralkyl)-4-acyl-2-piperazinones

Chemistry of Heterocyclic Compounds, 1986

piperazinones are formed in high yields during selective acy!ation of N-monosubstituted ethylenediamines by benzoyl and cyclohexylcarbonyl chlorides in the presence of pyridine hydrochloride and treatment of the reaction products with chloroacetyl chloride in the presence of potassium tert-butylate. Among 2-piperazinones, having different biological activities [1-3], the little investigated 4-acyl derivatives are of special interest, since the 4-acyl-2-piperazinone fragment is included in the structure of a new anthelmintic prasiquantel (I) [4] with a broad spectrum of activity. The aim of the present work was to find suitable method for the synthesis of l-alkyl(aralkyl)-4-acyl-2-piperazinones (IIa-g). Compounds IIa-g were selected as the object products, since they contain the same functional groups as prasiquantel, and have a similar lyophilicity. In the course of the investigation~ we studied schemes of synthesis of compound IIa-g, based on the use of available N-monosubstituted ethylenediamines IIIa-c.

Synthesis and Characterizations of New 1, 3-Oxazine Derivatives

2011

In this study, Betti's classical procedure, a Mannich-type aminoalkylation reaction of 2-naphthol with various aldehydes was applied in the presence of ammonia and then 1,3disubstituted-2,3-dihydro-1H-naphtoxazines were synthesized. The structures of the obtained new compounds have been clarified by spectroscopic methods and confirmed with elemental analysis results. From the synthesized compounds, 1,3-Di(2-naphthyl)-2,3-dihydro-1H-naphto[1,2-e][1,3]oxazine was investigation of the effects of solvent and concentration with UV-Visible Spectrophotometer. Additionally, this compound was analyzed the mutagenic and anti-mutagenic properties.

An Efficient and Solvent Free Synthesis of N-Aryl 2,3-Dihydro-4H naphtho-[2,1-e] 1,3-oxazines

Biomedical Journal of Scientific & Technical Research, 2020

Oxazine compounds have proved to have many pharmaceutical applications and most of these compounds now a days are used as drugs. For the importance of this class of heterocyclic compounds we are here investigate the synthesis of new derivatives of 1,3-oxazines using solvent free one pot three component system in a drug discovery program ,so starting from β-Naphthol, formaldehyde and aromatic amines in presence of zarconyl chloride as catalyst. compounds 1-9 were synthesized, Benzo 1,3 diazines (10-14) were also synthesized from their corresponding 1,3 oxazines. These compounds were characterized by IR, some representative by [1] HNMR and were discussed.