Synthesis and antituberculosis activity evaluation of cyclohexane-1,2-diamine derivatives CHEMISTRY & BIOLOGY INTERFACE (original) (raw)

Mycobacterium tuberculosis is responsible for a large number of deaths worldwide. This bacterium is a matter of great concern as it has developed resistance against most of the anti-TB drugs available today. A series of new cyclohexane-1,2-diamine derivatives was synthesized and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro. These compounds were found to be moderate to weakly active. Two compounds showed significant activity with minimum inhibitory concentrations of 11.8 and 13.1 µM (Optical Density).