Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase MK2
Duy Tiến Nguyễn
Journal of Molecular Biology, 2007
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Structural basis of inhibitor selectivity in MAP kinases
Sherin S. Abdel-Meguid
Structure, 1998
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Molecular docking and 3D-QSAR studies on the MAPKAP-K2 inhibitors
E. Pourbasheer
Medicinal Chemistry Research, 2014
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High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand
John Barker
Protein Science, 2009
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Structure-based lead identification of ATP-competitive MK2 inhibitors
Ruben Smeets
Bioorganic & Medicinal Chemistry Letters, 2011
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A computational strategy to understand structure-activity relationship of 1,3-disubstituted imidazole [1,5-α] pyrazine derivatives described as ATP competitive inhibitors of the IGF-1 receptor related to Ewing sarcoma
Alejandro Giorgetti
Journal of Molecular Modeling, 2020
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Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase ⊥ ⊥ Atomic coordinates and structure factors for crystal structure of compound 3d with p38α can be accessed using PDB code 3LHJ
Helen McBride, Ryan Wurz
Journal of Medicinal Chemistry, 2010
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Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity
Barry Springer, Crafford Harris
Archives of Biochemistry and Biophysics, 2006
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Evaluation of the combination mode and features of p38 MAPK inhibitors: construction of different pharmacophore models and molecular docking
liyu zhao
Molecular Simulation, 2019
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Dissection of the Recognition Properties of p38 MAP Kinase. Determination of the Binding Mode of a New Pyridinyl−Heterocycle Inhibitor Family
Modesto Orozco
Journal of Medicinal Chemistry, 2007
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Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors
Maria Letizia Barreca
Biochemical and Biophysical Research Communications, 2019
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Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
Stephen O'Keefe
Nature structural biology, 2003
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Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479
Jodie Pang
Bioorganic & Medicinal Chemistry Letters, 2014
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Complex Structure Modeling of p38 MAP Kinase and Pyridyl-pyrrole Compounds
Shuichi Miyamoto
Chem-Bio Informatics Journal, 2001
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Structural bases of protein kinase CK2 inhibition
Marco Mazzorana
2000
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In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I
Reiner Aichholz
Bioorganic & Medicinal Chemistry Letters, 2010
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Unravelling the structural interactions between PKR kinase domain and its small molecule inhibitors using computational approaches
Dr. Jayanta K . Pal
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Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors
Claire Delehouze
European journal of medicinal chemistry, 2016
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Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor
Desiree Fong
PLoS ONE, 2011
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Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3- d ]pyrimidine Inhibitors ‖
Hollis Showalter
Journal of Medicinal Chemistry, 1998
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Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804
Zara Walden
Biochemistry, 2009
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Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)
Jeffrey Madwed
Journal of Medicinal Chemistry, 2003
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The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer
Radha Akella
Structure, 2009
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p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses
Davide Moiani
Journal of Molecular Biology, 2009
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Structure-Based Design of 2-Arylamino-4-cyclohexylmethyl-5- nitroso-6-aminopyrimidine Inhibitors of Cyclin-Dependent Kinases 1 and 2
Kerry Sayle
Bioorganic & Medicinal Chemistry Letters, 2003
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Structure-based design and protein X-ray analysis of a protein kinase inhibitor
Pascal Furet
Bioorganic & Medicinal Chemistry Letters, 2002
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Elucidation of binding mode and three dimensional quantitative structure–activity relationship studies of a novel series of protein kinase B/Akt inhibitors
Yasar Saleem
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2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety
Mark Niosi
Journal of Medicinal Chemistry, 2018
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Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso- 6-aminopyrimidine inhibitors of cyclin-dependent kinase 2
Kerry Sayle
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3D-QSAR, DOCKING STUDY, PHARMACOPHORE MODELING AND ADMET PREDICTION OF 2- AMINO-PYRAZOLOPYRIDINE DERIVATIVES AS POLO-LIKE KINASE 1 INHIBITORS
firoz khan
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Structure‐guided discovery of cyclin‐dependent kinase inhibitors
Kamil Paruch
…, 2008
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Computational Insights for the Discovery of Non-ATP Competitive Inhibitors of MAP Kinases
Tamer Kaoud
Current Drug Metabolism, 2012
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A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera
Tatiana McHardy
Journal of Molecular Biology, 2007
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