In vivo complementation studies of a glycoprotein H-deleted herpes simplex virus-based vector (original) (raw)

This study investigates the establishment of latent infections and the efficacy of a glycoprotein H-deleted herpes simplex virus (HSV) vector in vivo. Using a mouse model, the researchers demonstrate the potential use of replication-deficient HSV vectors for gene delivery to the central nervous system (CNS) while ensuring safety by minimizing risks associated with recombination with wild-type viruses. The outcomes indicate that while certain viruses showed limited replication capabilities in sensory ganglia, their potential utility as vectors in gene therapy contexts is promising, warranting further exploration of their applications and mechanisms.