The relation between different dimensions of alcohol consumption and burden of disease: an overview (original) (raw)

The relationship between different dimensions of alcohol use and the burden of disease-an update

Addiction (Abingdon, England), 2017

Alcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative Risk Assessments (CRAs). Systematic review of reviews and meta-analyses on alcohol consumption and health outcomes attributable to alcohol use. For dimensions of exposure: volume of alcohol use, blood alcohol concentration and patterns of drinking, in particular heavy drinking occasions were studied. For liver cirrhosis, quality of alcohol was additionally considered. For all outcomes (mortality and/or morbidity): cause of death and disease/injury categories based on International Classification of Diseases (ICD) codes used in global CRAs; harm to others. In total, 255 reviews and meta-analyses were identified. Alcohol use was found to be linked causally to many disease and injury categories, with more than 40 ICD-10 three-digit categories being fully at...

Relation between Average Alcohol Consumption and Disease: An Overview

European Addiction Research, 2001

Objective: To conduct an overview of alcohol-related health consequences and to estimate relative risk for chronic consequences and attributable fractions for acute consequences. Methods: Identification of alcohol-related consequences was performed by means of reviewing and evaluating large-scale epidemiological studies and reviews on alcohol and health, including epidemiological contributions to major social cost studies. Relative risks and alcohol-attributable fractions were drawn from the international literature and risk estimates were updated, whenever possible, by means of meta-analytical techniques. Results: More than 60 health consequences were identified for which a causal link between alcohol consumption and outcome can be assumed. Conclusions: Future research on alcohol-related health consequences should focus on standardization of exposure measures and take into consideration both average volume of consumption and patterns of drinking.

Chronic diseases and conditions related to alcohol use

Alcohol research : current reviews, 2013

Alcohol consumption is a risk factor for many chronic diseases and conditions. The average volume of alcohol consumed, consumption patterns, and quality of the alcoholic beverages consumed likely have a causal impact on the mortality and morbidity related to chronic diseases and conditions. Twenty-five chronic disease and condition codes in the International Classification of Disease (ICD)-10 are entirely attributable to alcohol, and alcohol plays a component-risk role in certain cancers, other tumors, neuropsychiatric conditions, and numerous cardiovascular and digestive diseases. Furthermore, alcohol has both beneficial and detrimental impacts on diabetes, ischemic stroke, and ischemic heart disease, depending on the overall volume of alcohol consumed, and, in the case of ischemic diseases, consumption patterns. However, limitations exist to the methods used to calculate the relative risks and alcohol-attributable fractions. Furthermore, new studies and confounders may lead to add...

Alcohol Consumption Over Time and Risk of Death: A Systematic Review and Meta-Analysis

American Journal of Epidemiology, 2014

The results from the few cohort studies that have measured usual alcohol consumption over time have not been summarized. We therefore conducted a systematic review and meta-analysis to quantify mortality risk. Pertinent studies were identified by searching the Medline, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus, and Scopus databases through August 2012 using broad search criteria. Studies reporting relative mortality risks for quantitatively defined categories of alcohol consumption over time were eligible. Nine cohort studies published during 1991-2010 (comprising 62,950 participants and 10,490 deaths) met the inclusion criteria. For men, there was weak evidence of lower mortality risk with low levels of alcohol intake over time but higher mortality risk for those with intakes over 40 g/day compared with abstainers using a random-effects model (P for nonlinearity = 0.02). The pooled relative risks were 0.90 (95% confidence interval: 0.81, 0.99) for 1-29 g/day, 1.19 (95% confidence interval: 0.89, 1.58) for 30-59 g/day, and 1.52 (95% confidence interval: 0.78, 2.98) for 60 or more g/day compared with abstention. There was moderate between-study heterogeneity but no evidence of publication bias. Studies including women were extremely scarce. Our findings include a curvilinear association between drinking over time and mortality risk for men overall and widespread disparity in methods used to capture exposure and report results. alcohol consumption over time; meta-analysis; mortality; systematic review Abbreviations: CI, confidence interval; RR, relative risk.

EPIDEMIOLOGY OF ALCOHOL USE AND ALCOHOL-RELATED DISEASE CONDITIONS

Alcoholic beverages and the problems they engender have been familiar fixtures in human societies since the beginning of recorded history. Because alcohol is causally related to more than 60 International Classification of Diseases codes (Rehm, Room, Graham, and others 2003), disease outcomes are among the most important alcohol-related problems.

Alcohol Use and Non-Communicable Diseases, is there a Relationship

Texila International Journal of Public Health, 2020

Background and aims: The relationship between alcohol use and non-communicable disease prevalence has puzzled researchers for many years. Alcohol use is widely practiced globally and is believed to be a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes such as; cardiovascular diseases, chronic obstructive pulmonary diseases, diabetes and cancers. Methods: Systematic review of reviews and meta-analyses on chronic health outcomes attributable to alcohol use. For dimensions of exposure: volume of alcohol use, alcohol concentration and patterns of drinking, in particular heavy drinking occasions were studied. In total, 89 reviews and meta-analyses were searched in Google Scholar, PubMed, Medline but 28 reviews published from 2016 onwards were included in the study. Results: Most partly imputable illness classes showed monotonic relationships with volume of alcohol use: additional alcohol consumed posed a higher risk of disease or death. Exceptions were ischemic diseases and polygenic disease, with curvilinear relationships, and with beneficial effects of light to moderate drinking in people without heavy irregular drinking occasions. Biological pathways counsel a control of significant drinking occasions on further diseases; but, the lack of medical epidemiological studies measuring this dimension of alcohol use precluded an in-depth analysis. Conclusions: Research confirms alcohol use as both a risk factor for non-communicable diseases and at the same time protective when taken in moderation. However, further epidemiological studies should emphasize assessment of Health outcomes based on the quantity, frequency and concentration of the alcoholic drink.

Alcohol-attributable mortality and morbidity

Alcohol use is related to a wide variety of negative health outcomes including morbidity, mortality, and disability. Research on alcohol-related morbidity and mortality takes into account the varying effects of overall alcohol consumption and drinking patterns. The results from this epidemiological research indicate that alcohol use increases the risk for many chronic health consequences (e.g., diseases) and acute consequences (e.g., traffic crashes), but a certain pattern of regular light-to-moderate drinking may have beneficial effects on coronary heart disease. Several issues are relevant to the methodology of studies of alcohol-related morbidity and mortality, including the measurement of both alcohol consumption and the outcomes studied as well as study design. Broad summary measures that reflect alcohol's possible effects on morbidity, mortality, and disability may be more useful than measures of any one outcome alone.