Treatment Patterns for External Genital Warts in Australia, 1997 (original) (raw)
Related papers
Patterns of Treatment of External Genital Warts in Australian Sexual Health Clinics
Sexually Transmitted Diseases, 2009
Background: External genital warts are a common sexually transmitted viral disease. We describe the patterns of treatment for initial presentations of external genital warts (EGWs) in Australian sexual health centers. Methods: This was a retrospective audit of 489 case notes from consecutive individuals who presented with a new diagnosis of EGWs to 1 of 5 major sexual health clinics in Australia. Eligibility criteria were consecutive patients aged 18 to 45 years inclusively, presenting with first ever episode of EGWs from January 1, 2004. Exclusion criteria were patients who were immunocompromised, including HIV infection, or enrollment in a treatment study for EGWs. Results: The median age at presentation of women was 23.2 years and of men 26.8 years. One quarter (n ϭ 127) of patients had another sexually transmitted infection diagnosed at presentation. Nearly half of the patients (n ϭ 224) presented only once for treatment. Most often, patients were treated with a monotherapy (n ϭ 382/489; 78%), usually cryotherapy (257; 53%). Staff applied treatment in 361 (74%) cases. There was wide variation across sites, possibly reflecting local policies and budgets. We found no difference in wart resolution (n ϭ 292; 60%) by initial treatment chosen. Conclusions: The diagnosis and treatment of genital warts constitute a sizable proportion of clinical visits to the audited sexual health services and require a large input of staff time to manage, including the application of topical treatments. Our results help complete the picture of the burden of EGWs on Australian sexual health centers before the introduction of the HPV vaccine.
Sexually Transmitted Infections, 2003
Objectives: To evaluate the efficacy and cost effectiveness of self applied podophyllotoxin 0.5% solution and podophyllotoxin 0.15% cream, compared to clinic applied 25% podophyllin in the treatment of genital warts over 4 weeks. Methods: We conducted a randomised controlled trial in 358 immunocompetent men and women with genital warts of 3 months' duration or less. Results: In the principal analysis both podophyllotoxin solution (OR 2.93, 95% CI 1.56 to 5.50) and podophyllotoxin cream (OR 1.97, 95% CI 1.04 to 3.70) were associated with significantly increased odds of remission of all warts compared to podophyllin. We performed two further analyses. When subjects defaulting from follow up were assumed to have been cured odds of remission of all warts were also significantly increased both for podophyllotoxin solution (OR 3.04, 95% CI 1.68 to 5.49) and for podophyllotoxin cream (OR 2.46, 95% CI 1.38 to 4.40). When subjects defaulting from follow up were assumed not to have been cured odds of remission of all warts were significantly increased for podophyllotoxin solution (OR 1.92, 95% CI 1.13 to 3.27), but not for podophyllotoxin cream (OR 1.17, 95% CI 0.69 to 2.00). Local side effects were seen in 24% of subjects, and recurrence of warts within 12 weeks of study entry in 43% of all initially cleared subjects, without statistically significant differences between the treatment groups. Direct, indirect, and total costs were similar across the three treatment groups. Podophyllotoxin solution was the most cost effective treatment, followed by podophyllotoxin cream, with podophyllin treatment being the least cost effective. Conclusions: Self treatment of anogenital warts with podophyllotoxin showed greater efficacy and cost effectiveness than clinic based treatment with podophyllin.
Treatment of Genital Warts with a Combination of Cryotherapy and 5% Imiquimod
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020
A 34-year-old married; female patient came to the dermatology outpatient section with the chief complaint of raised lesions over her external genitalia for the past four months which were associated with itching. The lesions initially were smaller in size and which gradually increased to the present size. She took a consultation with a private practitioner, details of which were not available, but some oral medications were prescribed. However she failed to adhere to the treatment protocol.
Genital warts are the most commonly sexually transmitted viral infection of humans caused by Human Papillomavirus, affecting both male and female sexes, clinically characterized by the appearance of external warts on the genital organs including penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart ® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, acquired from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin 15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia. But the warts did not go off with the local brands of Dewart ® nor spontaneously recovered.
Journal of Obstetrics Gynecology and Cancer Research, 2017
Anogenital warts (AGWs) are the most prevalent sexually transmitted viral infections in the United States of America. Symptomatic warts can be seen in nearly 1% of the population aged 15 to 49 years. Genital warts are highly contagious through sexual contact. AGWs can be diagnosed by careful visual inspection. Several methods have been described for the treatment of warts; however, all have their own limitations and are not always successful. Warts often recur even after being completely removed. The treatments of warts can be divided into two broad categories, ie, surgical and nonsurgical methods. The patient himself/herself can apply the nonsurgical methods, or a physician can perform it. Podophyllotoxin is a good medical substance. Imiquimod can act as an immune response modifier and stimulate locally produced cytokine. Topical treatments of warts increase local production of interferon and decrease viral load of human papiloma virus (HPV). The surgical methods for genital warts include curettage, electrosurgery, and application of a scalpel under general or local anesthesia. Scattered keratinized lesions can be removed by electrosurgery. Patients with multiple or large warts of any location should be referred for surgical treatment under general anesthesia.
THE COST OF TREATING GENITAL WARTS
International Journal of Dermatology, 1996
Background. Genital warts is a common sexually transmitted disease treated by a variety of medical specialists. Standard therapies offer symptomatic relief but cannot ensure lasting remission. Using tbe clinical literature, claims databases, and a panel of experienced practitioners, tbe relative efficacy, cost, and cost effectiveness of five common treatments for genital warts were assessed in this study.
Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents
Biomedical Sciences, 2020
Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions reappeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.