High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia (original) (raw)

Six years after CR and 38 months after the end of the chemotherapy, the patient presented a relapse with lymphadenopathies without central nervous or BM localisation. Cytogenetic analysis on BM cells after 24 h culture showed a t(8;9) translocation as a sole abnormality in 16/29 metaphases. A novel lymph-node biopsy confirmed the relapse of T lymphoblastic lymphoma with a TDT þ , CD2 þ , CD3 þ , CD4À, CD5 þ , CD7 þ , CD8À, CD10À, CD30À, CD1AÀ, KITÀ phenotype, and P53 moderate overexpression. A high mitotic activity was evidenced with MIB1 antibody. The search for an association with Epstein-Barr virus was negative with LMP antibody. A second CR was obtained after ALL-like induction chemotherapy with the same drugs plus L-asparaginase. After three courses of consolidation including high doses aracytine and methotrexate, autologous stem cell transplantation was done in February 2005. The patient is still in CR 7 months after the graft and the karyotype established on BM in June 2005 was normal on 30 metaphases.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact