Study on quantitative dependence structure-antibacterial activity against Staphilococcus aureus in derivatives of 8-hydroxyquinoline (original) (raw)
Introduction. 8-hydroxyquinolin derivatives show antibacterial activity. Goal. The aim of this paper is to establish relationship between antibacterial acfivities of 8-hydroxyquinolin derivatives and their structure described by a set of electronic, steric, physicochemical and thermodynamic properties. Material and method. There were investigated 25 new compounds of S-hydroxyquinolines for which were determinate minimal inhibitory concentration (MIC, mg/dm3) against St.aureus. Results. Antibacterial activity was expressed through -lg (I/MIC) and seven descriptors was selected as independent variables influencing on the antibacterial activity. A regressional model between antibacterial activity and molecular structure descriptors was obtained. The R-squared value of the model is 0,988, which determined the model as adequate and with a high predictive ability. The model shall be helpful to predict biological activity of new sintesized compounds of this type and to outline the research for drug synthesis only to the compounds with high potential biological activity.
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