One-pot synthesis of pyrido[2,3-d]pyrimidine derivatives using sulfonic acid functionalized SBA-15 and the study on their antimicrobial activities (original) (raw)

2014, Journal of Saudi Chemical Society

AI-generated Abstract

This research presents a one-pot synthesis method for pyrido[2,3-d]pyrimidine derivatives utilizing sulfonic acid functionalized SBA-15 as a heterogeneous catalyst. In solvent-free conditions, the reaction between 6-aminouracil, various aromatic aldehydes, and malononitrile yielded high quantities of products, with the process optimized to complete in 5-45 minutes. Additionally, the synthesized compounds demonstrated antimicrobial activities against several bacteria and fungi, indicating their potential for pharmaceutical applications.