Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis (original) (raw)

International Surgery, 1998

Abstract

MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.

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