Synthesis and antiprotozoal activity of oligomethylene-and p-phenylene-bis(methylene)-linked bis(+)-huprines (original) (raw)
Huprines as a new family of dual acting trypanocidal–antiplasmodial agents
Xavier Formosa, Diego Muñoz-torrero
2011
View PDFchevron_right
Synthesis and Pharmacological Evaluation of Huprine−Tacrine Heterodimers: Subnanomolar Dual Binding Site Acetylcholinesterase Inhibitors
Pelayo Camps
Journal of Medicinal Chemistry, 2004
View PDFchevron_right
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents
Colin Wright
Bioorganic & medicinal chemistry, 2016
View PDFchevron_right
Design, synthesis, and antiprotozoal evaluation of new 2,9-bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline derivatives
PASCALE DOZOLME
Chemical biology & drug design, 2017
View PDFchevron_right
Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors
Pelayo Camps
Journal of Medicinal Chemistry, 2001
View PDFchevron_right
Synthesis and Antimalarial Evaluation of New 1,3,5-tris[(4-(Substituted-aminomethyl)phenyl)methyl]benzene Derivatives: A Novel Alternative Antiparasitic Scaffold
ioannis kanavos
2023
View PDFchevron_right
Bivalent Ligands Derived from Huperzine A as Acetylcholinesterase Inhibitors
Haim Haviv
Current Topics in Medicinal Chemistry, 2007
View PDFchevron_right
6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum
Yongyuth Yuthavong
Bioorganic & Medicinal Chemistry, 2019
View PDFchevron_right
Synthesis, anti-parasitic activity and QSAR study of a new library of polysubstituted tetrahydronaphtho[1,2-b]azepines
Ali Bahsas
Medicinal Chemistry Research, 2018
View PDFchevron_right
Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography
Florian Nachon
ChemMedChem, 2012
View PDFchevron_right
Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates
Maria Isabel Rodriguez-franco
ChemMedChem, 2010
View PDFchevron_right
Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine derivatives
Sandra Liliana Gomez Ayala, Ali Bahsas
Bioorganic & Medicinal Chemistry, 2010
View PDFchevron_right
Synthesis and antimalarial activity of hydroxyethylpiperazine derivatives
Marcele Moreth
European Journal of Medicinal Chemistry, 2009
View PDFchevron_right
Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation
Ben Dunn
PLOS ONE, 2015
View PDFchevron_right
Synthesis of 13-acylamino-huprines: Different behavior of diastereomeric 13-methanesulfonamido-huprines on PPA-mediated hydrolysis
Pelayo Camps
2004
View PDFchevron_right
Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine …
Julian Castrillon
Bioorganic & medicinal …, 2010
View PDFchevron_right
Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines
Mohammed Zabiulla
Journal of Medicinal Chemistry, 2012
View PDFchevron_right
Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring
alan kozikowski
Bioorganic & Medicinal Chemistry Letters, 1998
View PDFchevron_right
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity
Diego Muñoz-torrero, Stephen Gbedema
View PDFchevron_right
6-Arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors
Jonathan Baell
Journal of medicinal chemistry, 2015
View PDFchevron_right
Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, Part 2
Marcele Moreth
European Journal of Medicinal Chemistry, 2009
View PDFchevron_right
A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity
Gajanan S Inamdar
Experimental Parasitology, 2015
View PDFchevron_right
Synthesis of novel polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines as antiparasitic agents
Ali Bahsas
European Journal of Medicinal Chemistry, 2014
View PDFchevron_right