In VitroChondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells (original) (raw)

cartilage when implanted in vivo . A culture sys-A culture system that facilitates the chondrogenic tem has been developed in which these cells will undifferentiation of rabbit bone marrow-derived mesen-dergo osteogenic differentiation in vitro . However, chymal progenitor cells has been developed. Cells obattempts to develop in vitro conditions in which mesentained in bone marrow aspirates were first isolated by chymal progenitor cells isolated from postnatal mammonolayer culture and then transferred into tubes and malian bone marrow will progress down the chondroallowed to form three-dimensional aggregates in a genic lineage have been less successful. There are studchemically defined medium. The inclusion of 10 07 M ies reporting in vitro chondrogenesis using postnatal dexamethasone in the medium induced chondrogenic mammalian cells , but none have demonstrated differentiation of cells within the aggregate as evihistologically identifiable cartilage formation, although denced by the appearance of toluidine blue metachrotype II collagen production has been detected, sugmasia and the immunohistochemical detection of type gesting at least prechondroid tissue production.