Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein  -deficient mice (original) (raw)

Abstract

Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT͞enhancer binding protein (C͞EBP) is preferentially expressed in granulocytes and lymphoid cells. Mice with a null mutation in C͞EBP develop normally and are fertile but fail to generate functional neutrophils and eosinophils. Opportunistic infections and tissue destruction lead to death by 3-5 months of age. Furthermore, end-stage mice develop myelodysplasia, characterized by proliferation of atypical granulocytes that efface the bone marrow and result in severe tissue destruction. Thus, C͞EBP is essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells.

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