From rafts to crafts: membrane asymmetry in moving cells (original) (raw)
2003, Trends in Immunology
AI-generated Abstract
Persistent cell movement toward a directional signal, or chemotaxis, involves the establishment of functional and spatial cell polarity. This review discusses the pivotal role of membrane microdomains known as lipid rafts in the polarization process during cell migration. Raft reorganization facilitates the localization of proteins and signaling pathways, essential for maintaining asymmetry and directionality in moving cells. Despite advancements in imaging techniques, the detailed mechanisms linking raft dynamics to chemotactic responses remain underexplored, emphasizing the need for further research into the role of lipid rafts in cellular signaling and polarity.
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