Effects of Anethum graveolens leave powder on lipid profile in hyperlipidemic patients (original) (raw)
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2008
Background and the purpose of study: Anethum graveolens L. (Umbilliferae) is used in Iranian folk medicine as an anti-hypercholesterolaemic plant. The present study was carried out to determine the effect of Anethum graveolens extract (AGE) on serum lipoproteins in hypercholesterolaemic rats and also to determine its mechanism of action to some extant on liver hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase activity. Methods: The changes in serum triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using enzymatic kits. Hepatic HMG-CoA reductase activity was indirectly measured by the HMG CoA/mevalonate ratio. The amount of total phenolic and flavonoid compounds were also determined by common colorimetric methods. Results: Keeping the rats on a high-fat diet for 7 consecutive days increased the serum TC, TG and LDL-C levels significantly. However, the HDL-C level decreased relative to normal rats. Treatment of hyperlipidaemic rats with AGE (single daily dose of 1 ml, equivalent to 500 mg of the plant powder) and high-fat diet for up to 10 and/or 30 days reversed the serum lipid levels compared to rats which were fed only high-fat diet. In addition, our data indicated significant increase in HMG-CoA/mevalonate ratio as compared to rats which were fed high-fat diet after treatment with AGE for 30 days, indicating a decrease in the enzyme activity. Experiments showed that AGE has the phenolic and flavonoid content of 105.2 mg of gallic acid equivalents/g of the dried extract and 58.2 mg of catechin equivalents/g of the dried extract, respectively. Conclusion: The cumulative results clearly indicate that A. graveolens possesses potent hypocholesterolaemic effects in rats probably mediated through the suppression of endogenous cholesterol biosynthesis by inhibition of the activity of HMG-CoA reductase.
International journal of preventive medicine, 2013
We aimed to determine the effects of Anethum graveolens (Dill) powder on postprandial lipid profile, markers of oxidation and endothelial activation when added to a fatty meal. In an experimental study, 32 rabbits were randomly designated into four diet groups: normal diet, high cholesterol diet (1%), high cholesterol diet plus 5% (w/w) dill powder and high cholesterol diet plus lovastatin (10 mg/kg, bw). The concentrations of glucose, total cholesterol (TC), low-density lipoproteins-cholesterol (LDL-C), alanine aminotransferase (alt), aspartate aminotransferase (ast), fibrinogen, factor VII, apolipoprotein B (ApoB), nitrite and nitrate were measured in blood samples following 15 h of fasting and 3 h after feeding. Concurrent use of A. graveolens powder or lovastatin significantly decreased ALT, TC, glucose, fibrinogen and LDL-C values in comparison with hypercholesterolemic diet group (P < 0.05). Consumption of A. graveolens or lovastatin did not change factor VII, ApoB, nitrite...
The Role ofAnethum graveolensL. (Dill) in the Management of Diabetes
Journal of Tropical Medicine, 2016
Aim. There is evidence that Anethum graveolens (AG) has been used for centuries in Asian traditional medicine, and its constituents have useful effects on the control and management of diabetes and cardiovascular disorders. AG has many useful effects, including hypolipidemic and hypoglycemic effects, and it has been reported to reduce the incidence of diabetic complications. It acts mainly by affecting antioxidant capacity and change in some genes in glucose and lipid pathways. The aim of the present paper was to summarize pharmacological effects of AG in the management of diabetes. Methods. To prepare this review, a pharmacological and phytochemical literature survey was performed using Scopus, PubMed, and Web of Science. Also, some historical and ethnopharmacological literature sources were used. Results. This review plans to provide readers with an assessment of the pharmacological effects of AG, especially in diabetes. Conclusion. The paper highlights the therapeutic effects of AG which would aid in supporting their safe use in the management of diabetes and cardiovascular diseases.
Annals of Tropical Medicine and Public Health, 2020
1 Department of Food Science and Technology, College of Food Sciences, Al-Qasim green University, Iraq. ZahraaReasan@fosci.uoqasim.edu.iq 2 Department of Food Health and Nutrition, College of Food Sciences, Al-Qasim green University, Iraq. Armulakhudair1@fosci.uoqasim.edu.iq 3 Department of Food Science and Technology, College of Food Sciences, Al-Qasim green University, Iraq. MunaNajmKhalaf@fosci.uoqasim.edu.iq Abstract:
The Role of Anethum graveolens L. (Dill) in the Management of Diabetes
Journal of Tropical Medicine, 2016
Aim. There is evidence thatAnethum graveolens(AG) has been used for centuries in Asian traditional medicine, and its constituents have useful effects on the control and management of diabetes and cardiovascular disorders. AG has many useful effects, including hypolipidemic and hypoglycemic effects, and it has been reported to reduce the incidence of diabetic complications. It acts mainly by affecting antioxidant capacity and change in some genes in glucose and lipid pathways. The aim of the present paper was to summarize pharmacological effects of AG in the management of diabetes.Methods. To prepare this review, a pharmacological and phytochemical literature survey was performed using Scopus, PubMed, and Web of Science. Also, some historical and ethnopharmacological literature sources were used.Results. This review plans to provide readers with an assessment of the pharmacological effects of AG, especially in diabetes.Conclusion. The paper highlights the therapeutic effects of AG wh...
Safety evaluation of oral Anethum graveolens L total hydroalcoholic extract in mice
Anethum graveolens L. (dill) is used widely in Asian food and folk medicine but its safety profile for further clinical studies has remained unclear. After administration of total hydroalcoholic extract to mice in acute, subacute and subchronic treatment periods, toxic responses were recoreded by clinical, biochemical, hematological and pathological examinations. Doses up to 2000 mg/kg in acute study did not cause any mortality and doses up to 1000 mg/kg didn't cause any toxic effect in subacute study. Following to daily administration of doses of 1000 mg/kg/day as Maximum Tolerated Dose (MTD) and doses of 50 (1/20 MTD), 500 (1/2MTD) and 1000 mg/kg (MTD) in 45 days regimen, signif cant falls in white cell counts was reported after 3 weeks (P-value < 0.05) in high (P-value = 0.042) and intermediate dose (P-value = 0.018) groups of male animals. Dill extract caused significant reduction of FBS in high dose female animal group (P-value = 0.021). Portal mononuclear lymphoid and PMN leucocytes infiltration in three adjacent foci were seen in intermediate and high dose groups of both sexes which was clearly a dose dependent effect. Doses less than 50 mg/kg could be consi ered as safe dose in both genders of mice with the good potential for further antihypoglycemic or antihyperlipidemic clinical studies.
2015
Increasing blood lipids, particularly cholesterol and triglyceride levels are dangerous factors causing cardiovascular disease and myocardial infarction in humans. The aim of this study was to investigate the effect of drinkable hydroalcoholic extract of dill on the serum cholesterol, Triglycerides, LDL and HDL levels. This study was conducted on 18 male NMRI mice. The mice were divided into 3 groups (n=6). The first group was given tap water as the control group. The second group, the extract at a dose of 250 mg / lit and the third group extract at a dose of 500 mg / lit were given in drinking water for 30 days. After the period of treatment under complete anesthesia, blood samples were taken from animals and serum cholesterol, triglycerides, LDL and HDL levels were measured. The result showed that consumption of hydroalcoholic extract of dill results in significant reducing of cholesterol, triglycerides and LDL in both extract - receiving groups compared to control group(P<0.00...
Placebo-Controlled Study on Comparison of Two Herbal Hypolipidemic Agents
Journal of Drug Delivery and Therapeutics, 2016
Introduction: Hyperlipidemia, either primary or secondary causes atherogenetic abnormalities leading to coronary artery disease, cardiac arrest and arrhythmias. Herbal therapy for prevention or cure of Hyperlipidemia is replacing allopathic medicine due to their bioequivalence and good compliance features. This study was conducted to compare hypolipidemic effects of Garlic and Nigella sativa. Place of Study: Study was conducted at Jinnah Hospital Lahore from July 2013 to December 2013. Seventy five hyperlipidemic patients were enrolled after getting written consent which was approved by Ethics committee of the hospital. Grouping: They were divided in three equal groups comprising 25 patients in each group. Group-A was treated by Nigella Sativa, Group-B was advised to take Garlic 10 grams twice daily for two months. Group-C was on placebo. Results: After two months therapy it was observed by statistical analysis that Nigella sativa decreased total cholesterol 12.4 mg/dl, triglycerides 16.7 mg/dl, and LDL cholesterol 27.3 mg/dl. HDL rise was 5.2 mg/dl. Garlic decreased total cholesterol 17.9 mg/dl, triglycerides 19.9 mg/dl and LDL cholesterol 14.8 mg/dl. HDL cholesterol rise was 8.0 mg/dl. Conclusion: It was concluded from this study that there is little difference between hypolipidemic effects of two important and famous herbal medicines ie, Nigella sativa and Garlic.