Therapeutic angiogenesis following intramuscular gene transfer of vascular endothelialgrowth factor 121 in a dog model of hindlimb ischemia (original) (raw)

2003, Electronic Journal of Biotechnology

AI-generated Abstract

This study investigates the effects of intramuscular gene transfer of vascular endothelial growth factor (VEGF) 121 in a dog model of hindlimb ischemia. Following the surgical induction of unilateral hindlimb ischemia in Beagle dogs, the administration of naked plasmid DNA encoding VEGF 121 resulted in enhanced angiogenesis, as evidenced by increased collateral vessels and improved limb perfusion compared to controls. The findings suggest that VEGF 121 gene therapy may offer a novel approach for treating critical limb ischemia.