No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates (original) (raw)

The study investigates the incidence of osteonecrosis of the jaw (ONJ) in young patients suffering from osteogenesis imperfecta (OI) who are treated with bisphosphonates, particularly disodium pamidronate (APD). The research reveals no cases of ONJ among a group of 22 OI patients who underwent surgical treatments while on bisphosphonate therapy. Although the sample size is small, the findings suggest that bisphosphonate therapy poses a low risk for ONJ in this specific population, advocating for continued treatment to provide the symptomatic benefits for severe OI.