Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress (original) (raw)

Carbon Monoxide Induces Cardiac Arrhythmia via Induction of the Late Na+ Current

American Journal of Respiratory and Critical Care Medicine, 2012

Rationale: Clinical reports describe life-threatening cardiac arrhythmias following environmental exposure to carbon monoxide (CO) or accidental CO poisoning. Numerous case studies describe disruption of repolarization and prolongation of the QT interval, yet the mechanisms underlying CO-induced arrhythmias are unknown. Objectives: to understand the cellular basis of CO-induced arrhythmias and to indentify an effective therapeutic approach. Methods: Patch-clamp electrophysiology and confocal Ca2+ and nitric oxide ( ...