Alcohol Intake After Serotonin Transporter Inactivation in Mice (original) (raw)

This study investigates the role of serotonin transporter (5-HTT) in alcohol consumption using genetically modified mice lacking the 5-HTT gene. The findings reveal that 5-HTT-/- mice exhibit significantly lower alcohol intake compared to wild-type mice, and that treatment with fluoxetine, a selective serotonin reuptake inhibitor, effectively reduces alcohol consumption in wild-type mice but not in the mutants. These results suggest that inhibition of 5-HT reuptake is a viable target for reducing alcohol consumption in dependent individuals.