Observations concerning the correlation ofin vitro sulfonamide activity with pKa and the hammett values (original) (raw)

1967, Journal of Pharmaceutical Sciences

Anal.-Calcd. for C6HaN6018: N, 18.59. Found: min., the product was washed with dilute sodium N, 18.50. carbonate solution, water, and ether and crystallized Hexubenzoute-Prepared by treating the substance from ethanol. The condensation product melted with benzoyl chloride in presence of pyridine, m.p. a t 220" (corrected) (cf. m.p. 223-224') (4). 148' (corrected). densation (4) of D-mannitol (100 mg.) with benzaldehyde (200 mg.) was more satisfactorily achieved using phosphorus pentoxide (100 mg.) or con-(3) Gupta, S. S., et al., unpublished data. centrated sulfuric acid ( 2 drops), than with concentrated HC1. After shaking the mixture for 15 REFERENCES Plants," vol. 111. Lalit Mohan Basu, Allahabad, 1933, p. 1948. , ,~~~~~f " , " , e a v ; m K 2~; ~~slagv6dqa): s. Linear correlations of the in vitro bacteriostatic activity of sulfonamides with pKa provide little evidence in support of there being a definite pKa which a sulfonamide must possess in order to exhibit maximum activity.