An oxytetracycline residue depletion study to assess the physiologically based pharmokinetic (PBPK) model in farmed Atlantic salmon (original) (raw)

1997, The Canadian veterinary journal. La revue vétérinaire canadienne

AI-generated Abstract

A study was conducted to evaluate the effectiveness of a physiologically based pharmacokinetic (PBPK) model in predicting oxytetracycline (OTC) residue depletion in farmed Atlantic salmon. Two dosing regimes were analyzed: one with OTC administered for 10 days and another for 14 days. The study found that OTC concentrations varied among fish, with the highest levels found in the liver and the lowest in muscle. The PBPK model predicted that residue levels would drop below the tolerance limit at earlier times than the traditional pharmacokinetic approach, suggesting potential for improved withdrawal times and therapeutic efficacy in aquaculture.

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