In vivo and microsomal metabolism of the pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine by the Syrian golden hamster (original) (raw)

A/-Nitrosobis(2-oxopropyl)amine (BOP), a /^-oxidized metab olite of di-n-propylnitrosamine, is a potent carcinogen of the pancreas in Syrian golden hamsters. In the present studies, we investigated the in vivo metabolism of BOP in hamsters as well as its in vitro metabolism by the hamster pancreatic, liver, kidney, and lung microsomes. Data are also presented utilizing high-pressure liquid chromatography separation methodology for the BOP metabolites, /V-nitroso(2-hydroxypropyl)(2-oxopro-pyDamine (HPOP) and iV-nitrosobis(2-hydroxypropyl)amine (BMP).