Predictors of early recurrence for node-negative t1 to t2b non-small cell lung cancer (original) (raw)
The Annals of thoracic surgery, 2014
Abstract
Recurrence develops in nearly one-third of patients who undergo complete resection for non-small cell lung cancer (NSCLC). We sought to identify predictors of early recurrence (<2 years) in node-negative T1 to T2b NSCLC. We used a 10-year (1999 to 2008) single-institution retrospective review of a prospectively maintained lung cancer database. Exclusion criteria included carcinoid, adenocarcinoma in situ, and minimally invasive adenocarcinoma histologies, and any induction therapy. Patient demographics, clinical, and pathologic variables were analyzed. Recurrence was confirmed histologically in 86 patients (85%) or radiographically in 16 (15%). Univariable and multivariable logistic regression (C statistic = 0.7) and Cox proportional hazards analyses were performed (p < 0.05 is significant). An R0 resection of a node-negative T1 to T2b NSCLC was performed in 532 patients. Procedures included lobectomy in 436, segmentectomy in 47, and wedge…
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