Early recruitment of natural CD41Foxp31 Treg cells by infective larvae determines the outcome of filarial infection (original) (raw)

2000

Abstract

Human helminth infections are synonymous with impaired immune responsiveness indicating suppression of host immunity. Using a permissive murine model of filariasis, Litomosoides sigmodontis infection of inbred mice, we demonstrate rapid recruitment and increased in vivo proliferation of CD41Foxp31 Treg cells upon exposure to infective L3 larvae. Within 7 days post-infection this resulted in an increased percentage of CD41 T cells

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