Estrogen Receptor-α But Not -β or GPER Inhibits High Glucose-Induced Human VSMC Proliferation: Potential Role of ROS and ERK (original) (raw)

The study investigates the differential effects of estrogen receptor subtypes (ERα, ERβ, and GPER) on the proliferation of human vascular smooth muscle cells (VSMCs) under high glucose (HG) conditions, which are relevant to atherosclerosis in diabetic patients. It finds that only ERα significantly inhibits VSMC proliferation in HG environments through mechanisms involving reactive oxygen species (ROS) and ERK phosphorylation. The findings suggest a potentially important role for ERα in therapeutic strategies for vascular diseases exacerbated by hyperglycemia.