Central interleukin-1β-induced inhibition of acid secretion in rats: Specificity of action (original) (raw)
AI-generated Abstract
The study investigates the mechanism behind the inhibition of gastric acid secretion induced by interleukin-1 beta (IL-1β) in conscious rats, specifically focusing on its central effects. Through intracerebroventricular administration, it was found that IL-1β significantly decreased acid secretion, and this effect was reversible by IL-1 receptor antagonists, indicating a specific interaction. The findings suggest that IL-1β’s antisecretory action operates independently of somatostatin and relies primarily on prostaglandin pathways.
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