The characterization of dendronized poly(ethylene glycol)s and poly(ethylene glycol) multi-arm stars using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (original) (raw)

The paper examines dendronized poly(ethylene glycol)s (dPEGs) and multi-arm star poly(ethylene glycol)s (starPEGs) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) as a characterization tool. The unique structural features of these polymers enhance their functionality for biological applications, aiding in the development of polymeric drug carriers. Through comparative analysis using MALDI-ToF MS, the reliability of different synthetic pathways, including the 'core first' approach for starPEGs and the dendronization method for dPEGs, is established, highlighting their respective merits and challenges.